{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["65"],"submitter":["Chatzikonstantinou T"],"pubmed_abstract":["<h4>Background</h4>Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work.<h4>Methods</h4>We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022.<h4>Findings</h4>In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs w"],"journal":["EClinicalMedicine"],"pagination":["102307"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10685149"],"repository":["biostudies-literature"],"pubmed_title":["Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY."],"pmcid":["PMC10685149"],"pubmed_authors":["Catherwood M","Mulligan S","Phumphukhieo P","Angelopoulou M","Guarente V","Doubek M","Kotaskova J","Minga E","Marquet J","Shen Y","Daniel de Deus Santos M","Stavroyianni N","Espinet B","Jaksic O","Fresa A","Yanez L","Oscier D","Collado R","Levy I","Dreta B","El-Ashwah S","Laurenti L","Gogia A","Pospisilova S","Hernandez-Rivas JA","Murru R","Xu Z","Bellido M","Cuneo A","Kubova Z","Gonzalez-Gascon-Y-Marin I","Papajik T","Puiggros A","Al-Shemari S","Chamou D","Morawska M","Enrico A","Lopez-Garcia A","Claus R","Vitale C","Pierie C","Schiwitza A","Popov VM","Rigolin GM","Chatzileontiadou S","Stamatopoulos K","Gupta R","Kislova M","Demirkan F","Gimeno E","Panagiotidis P","Kho B","Labrador J","Maynadie M","Kater AP","Tam C","Visentin A","Dimou M","Biderman B","Navarro-Bailon A","Janssen S","Smolej L","Bijou F","Khan MA","Konstantinou E","Rani L","Inchiappa L","Davis Z","Vassilakopoulos T","Oliveira AC","Coscia M","Papaioannou M","Kreitman RJ","Lad D","Efstathopoulou M","Levin MD","Schipani M","Nikitin E","Vukovic V","Kotsianidis I","Cassin R","Reda G","Wasik-Szczepanek E","Tse E","Smirnova S","Zuchnicka J","von Tresckow J","Panovska-Stavridis I","Longval T","Pangalis GA","Laribi K","Mayor-Bastida C","Aurran-Schleinitz T","Bacchiarri F","Galimberti S","Yagci M","Antic D","Bosch F","Moia R","Abdelrahman Soliman DS","Karakus V","Maslejova S","Iacoboni G","Koren-Michowitz M","Hatzimichael E","Garcia-Serra R","Ruchlemer R","Trentin L","Herishanu Y","Walewska R","Gozzetti A","Sportoletti P","Vrachiolias G","Scarfo L","Tomic K","Yassin M","Olivieri J","Simkovic M","Spacek M","Calleja A","Santos GD","Chatzidimitriou A","Tadmor T","Ghia P","Demosthenous C","Alcoceba M","Galitzia A","Chatzikonstantinou T","Christian A","Kalashnikova OB","Guieze R","Kalicinska E","Milosevic I","Miras F","Karakatsoulis G","Martin-Rodriguez L","Nath UK","Harrop S","Mihaljevic B","Medina A","Gaidano G","Donaldson D"],"additional_accession":[]},"is_claimable":false,"name":"Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY.","description":"<h4>Background</h4>Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work.<h4>Methods</h4>We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022.<h4>Findings</h4>In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs w","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-07-16T14:34:37.469Z","creation":"2025-02-19T00:01:22.436Z"},"accession":"S-EPMC10685149","cross_references":{"pubmed":["38033506"],"doi":["10.1016/j.eclinm.2023.102307"]}}