biostudies-literatureUnknown65Chatzikonstantinou T<h4>Background</h4>Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work.<h4>Methods</h4>We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022.<h4>Findings</h4>In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs wEClinicalMedicine102307https://www.ebi.ac.uk/biostudies/studies/S-EPMC10685149biostudies-literatureOther malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY.PMC10685149Catherwood MMulligan SPhumphukhieo PAngelopoulou MGuarente VDoubek MKotaskova JMinga EMarquet JShen YDaniel de Deus Santos MStavroyianni NEspinet BJaksic OFresa AYanez LOscier DCollado RLevy IDreta BEl-Ashwah SLaurenti LGogia APospisilova SHernandez-Rivas JAMurru RXu ZBellido MCuneo AKubova ZGonzalez-Gascon-Y-Marin IPapajik TPuiggros AAl-Shemari SChamou DMorawska MEnrico ALopez-Garcia AClaus RVitale CPierie CSchiwitza APopov VMRigolin GMChatzileontiadou SStamatopoulos KGupta RKislova MDemirkan FGimeno EPanagiotidis PKho BLabrador JMaynadie MKater APTam CVisentin ADimou MBiderman BNavarro-Bailon AJanssen SSmolej LBijou FKhan MAKonstantinou ERani LInchiappa LDavis ZVassilakopoulos TOliveira ACCoscia MPapaioannou MKreitman RJLad DEfstathopoulou MLevin MDSchipani MNikitin EVukovic VKotsianidis ICassin RReda GWasik-Szczepanek ETse ESmirnova SZuchnicka Jvon Tresckow JPanovska-Stavridis ILongval TPangalis GALaribi KMayor-Bastida CAurran-Schleinitz TBacchiarri FGalimberti SYagci MAntic DBosch FMoia RAbdelrahman Soliman DSKarakus VMaslejova SIacoboni GKoren-Michowitz MHatzimichael EGarcia-Serra RRuchlemer RTrentin LHerishanu YWalewska RGozzetti ASportoletti PVrachiolias GScarfo LTomic KYassin MOlivieri JSimkovic MSpacek MCalleja ASantos GDChatzidimitriou ATadmor TGhia PDemosthenous CAlcoceba MGalitzia AChatzikonstantinou TChristian AKalashnikova OBGuieze RKalicinska EMilosevic IMiras FKarakatsoulis GMartin-Rodriguez LNath UKHarrop SMihaljevic BMedina AGaidano GDonaldson DfalseOther malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY.<h4>Background</h4>Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work.<h4>Methods</h4>We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022.<h4>Findings</h4>In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs w2023-01-01T00:00:00Z2023 Nov2026-07-16T14:34:37.469Z2025-02-19T00:01:22.436ZS-EPMC106851493803350610.1016/j.eclinm.2023.102307