biostudies-literatureUnknown4(11)Gruber M<h4>Background</h4>Atrial fibrillation (AF) increases heart failure (HF) risk. Whereas the risk of HF-related hospitalization and mortality are known in the setting of AF, the impact of AF treatment on HF development is understudied.<h4>Objective</h4>The purpose of this study was to compare HF incidence among AF patients treated with antiarrhythmic drugs (AADs) vs catheter ablation (CA).<h4>Methods</h4>AF patients with 1 prior AAD usage were identified in 2014-2022 Optum Clinformatics database. Patients were classified into 2 cohorts: those receiving CA vs those receiving a different AAD prescription. The 2 cohorts were matched on sociodemographic and clinical covariates using propensity score matching technique. Cox regression model was used to compare incident HF risk in the 2 cohorts. SHeart rhythm O2681-691https://www.ebi.ac.uk/biostudies/studies/S-EPMC10685151biostudies-literatureHeart failure risk in patients with atrial fibrillation treated with catheter ablation vs antiarrhythmic drugs.PMC10685151Karim SZhang DGruber MKhanna RIglesias MfalseHeart failure risk in patients with atrial fibrillation treated with catheter ablation vs antiarrhythmic drugs.<h4>Background</h4>Atrial fibrillation (AF) increases heart failure (HF) risk. Whereas the risk of HF-related hospitalization and mortality are known in the setting of AF, the impact of AF treatment on HF development is understudied.<h4>Objective</h4>The purpose of this study was to compare HF incidence among AF patients treated with antiarrhythmic drugs (AADs) vs catheter ablation (CA).<h4>Methods</h4>AF patients with 1 prior AAD usage were identified in 2014-2022 Optum Clinformatics database. Patients were classified into 2 cohorts: those receiving CA vs those receiving a different AAD prescription. The 2 cohorts were matched on sociodemographic and clinical covariates using propensity score matching technique. Cox regression model was used to compare incident HF risk in the 2 cohorts. S2023-01-01T00:00:00Z2023 Nov2025-04-26T00:17:37.663Z2025-04-06T09:41:09.463ZS-EPMC106851513803488510.1016/j.hroo.2023.09.009