{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Calarco N"],"funding":["NIMH NIH HHS","National Institute of Mental Health"],"pagination":["1518-1529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10686342"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(6)"],"pubmed_abstract":["<h4>Background and hypothesis</h4>Neurocognitive and social cognitive abilities are important contributors to functional outcomes in schizophrenia spectrum disorders (SSDs). An unanswered question of considerable interest is whether neurocognitive and social cognitive deficits arise from overlapping or distinct white matter impairment(s).<h4>Study design</h4>We sought to fill this gap, by harnessing a large sample of individuals from the multi-center Social Processes Initiative in the Neurobiology of the Schizophrenia(s) (SPINS) dataset, unique in its collection of advanced diffusion imaging and an extensive battery of cognitive assessments. We applied canonical correlation analysis to estimates of white matter microstructure, and cognitive performance, across people with and without an SS"],"journal":["Schizophrenia bulletin"],"pubmed_title":["Multivariate Associations Among White Matter, Neurocognition, and Social Cognition Across Individuals With Schizophrenia Spectrum Disorders and Healthy Controls."],"pmcid":["PMC10686342"],"funding_grant_id":["3/3R01MH102318–01","2/3R01MH102313–01","R01 MH102324","R01 MH102313","R01 MH102318","1/3R01MH102324–01","1/3R01MH102324-01"],"pubmed_authors":["DeRosse P","Buchanan RW","Voineskos AN","Joseph M","Dickie EW","Gold JM","Argyelan M","Malhotra AK","Oliver LD","Calarco N","Hawco C","Foussias G"],"additional_accession":[]},"is_claimable":false,"name":"Multivariate Associations Among White Matter, Neurocognition, and Social Cognition Across Individuals With Schizophrenia Spectrum Disorders and Healthy Controls.","description":"<h4>Background and hypothesis</h4>Neurocognitive and social cognitive abilities are important contributors to functional outcomes in schizophrenia spectrum disorders (SSDs). An unanswered question of considerable interest is whether neurocognitive and social cognitive deficits arise from overlapping or distinct white matter impairment(s).<h4>Study design</h4>We sought to fill this gap, by harnessing a large sample of individuals from the multi-center Social Processes Initiative in the Neurobiology of the Schizophrenia(s) (SPINS) dataset, unique in its collection of advanced diffusion imaging and an extensive battery of cognitive assessments. We applied canonical correlation analysis to estimates of white matter microstructure, and cognitive performance, across people with and without an SS","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-07-14T16:25:17.247Z","creation":"2025-04-07T01:06:03.429Z"},"accession":"S-EPMC10686342","cross_references":{"pubmed":["36869812"],"doi":["10.1093/schbul/sbac216"]}}