{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zlatanova I"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NIH HHS"],"pagination":["eadh5313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10686572"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(48)"],"pubmed_abstract":["Mammals have limited capacity for heart regeneration, whereas zebrafish have extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells promote cardiomyocyte cell cycle reentry and myocardial repair, but the mechanisms responsible for promoting an injury microenvironment conducive to regeneration remain incompletely defined. Here, we identify the matrix metalloproteinase Mmp14b as an essential regulator of heart regeneration. We identify a TEAD-dependent <i>mmp14b</i> endothelial enhancer induced by heart injury in zebrafish and mice, and we show that the enhancer is required for regeneration, supporting a role for Hippo signaling upstream of <i>mmp14b</i>. Last, we show that MMP-14 function in mice is important for the accumulation of Agrin, an essential "],"journal":["Science advances"],"pubmed_title":["An injury-responsive <i>mmp14b</i> enhancer is required for heart regeneration."],"pmcid":["PMC10686572"],"funding_grant_id":["P01 HL146366","R01 DK119621","R01HL160819 (G.N.H.), R01HL138456 (G.N.H.), DK119621 (B.L.B.), AND HL146366 (B.L.B.).","R01 HL160819","R01 HL138456"],"pubmed_authors":["Xu SM","Black BL","Sinha T","Celona B","Materna SC","Sun F","Lau BH","Chen X","Huang GN","Zlatanova I","Wu RS","Colombier P"],"additional_accession":[]},"is_claimable":false,"name":"An injury-responsive <i>mmp14b</i> enhancer is required for heart regeneration.","description":"Mammals have limited capacity for heart regeneration, whereas zebrafish have extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells promote cardiomyocyte cell cycle reentry and myocardial repair, but the mechanisms responsible for promoting an injury microenvironment conducive to regeneration remain incompletely defined. Here, we identify the matrix metalloproteinase Mmp14b as an essential regulator of heart regeneration. We identify a TEAD-dependent <i>mmp14b</i> endothelial enhancer induced by heart injury in zebrafish and mice, and we show that the enhancer is required for regeneration, supporting a role for Hippo signaling upstream of <i>mmp14b</i>. Last, we show that MMP-14 function in mice is important for the accumulation of Agrin, an essential ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-19T11:34:35.712Z","creation":"2025-04-19T11:34:35.712Z"},"accession":"S-EPMC10686572","cross_references":{"pubmed":["38019918"],"doi":["10.1126/sciadv.adh5313"]}}