{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Matsuzaki T"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["As cells age, they undergo a remarkable global change: In <i>transcriptional drift</i>, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging <i>Caenorhabditis elegans</i> worms, we find that the upregulated genes code for sensory proteins upstream of stress responses and downregulated genes are growth- and metabolism-related. We propose a simple mechanistic model for how such global coordination of multi-protein expression levels may be achieved by the binding of a single ligand that concentrates with age. A key implication is that a cell's own responses are part of its aging process, so unlike for wear-and-tear processes, intervention might be able to modulate these effects."],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.11.21.568122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10690170"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional drift in aging cells: A global de-controller."],"pmcid":["PMC10690170"],"funding_grant_id":["R35 GM122561"],"pubmed_authors":["Matsuzaki T","de Graff A","Dill KA","Balazsi G","Weistuch C"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional drift in aging cells: A global de-controller.","description":"As cells age, they undergo a remarkable global change: In <i>transcriptional drift</i>, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging <i>Caenorhabditis elegans</i> worms, we find that the upregulated genes code for sensory proteins upstream of stress responses and downregulated genes are growth- and metabolism-related. We propose a simple mechanistic model for how such global coordination of multi-protein expression levels may be achieved by the binding of a single ligand that concentrates with age. A key implication is that a cell's own responses are part of its aging process, so unlike for wear-and-tear processes, intervention might be able to modulate these effects.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-08-18T09:53:03.736Z","creation":"2025-04-05T23:54:21.991Z"},"accession":"S-EPMC10690170","cross_references":{"pubmed":["38045342"],"doi":["10.1101/2023.11.21.568122"]}}