{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mein N"],"funding":["Interdisciplinary Center of Clinical Research","Center for Sepsis Control and Care, Jena, Germany","Schilling Foundation","German Research Council","German Center for Mental Health; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany","Universitätsklinikum Jena"],"pagination":["289"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10691003"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and is associated with poor outcome in the early phase of sepsis. In addition, sepsis survivors often suffer from persisting memory deficits and impaired executive functions. Recent studies provide evidence that microglia are involved in the pathophysiology of SAE.<h4>Methods</h4>Here, we investigated whether pharmacological depletion of microglia using PLX5622 (1200 ppm or 300 ppm) in the acute phase of sepsis is able to prevent long-term neurocognitive decline in a male mouse model of polymicrobial sepsis or lipopolysaccharide-induced sterile neuroinflammation. Therefore, we performed the novel object recognition test at d"],"journal":["Journal of neuroinflammation"],"pubmed_title":["Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis."],"pmcid":["PMC10691003"],"funding_grant_id":["GE2519/8-1","GE2519/9-1"],"pubmed_authors":["Geis C","Chung HY","von Stackelberg N","Wickel J","Mein N"],"additional_accession":[]},"is_claimable":false,"name":"Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis.","description":"<h4>Background</h4>Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and is associated with poor outcome in the early phase of sepsis. In addition, sepsis survivors often suffer from persisting memory deficits and impaired executive functions. Recent studies provide evidence that microglia are involved in the pathophysiology of SAE.<h4>Methods</h4>Here, we investigated whether pharmacological depletion of microglia using PLX5622 (1200 ppm or 300 ppm) in the acute phase of sepsis is able to prevent long-term neurocognitive decline in a male mouse model of polymicrobial sepsis or lipopolysaccharide-induced sterile neuroinflammation. Therefore, we performed the novel object recognition test at d","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-29T00:37:50.103Z","creation":"2024-11-08T16:26:52.794Z"},"accession":"S-EPMC10691003","cross_references":{"pubmed":["38041192"],"doi":["10.1186/s12974-023-02975-8"]}}