{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang J"],"funding":["National Key R&D Program of China","National Natural Science Foundation of China","Beijing Science and Technology Planning Project"],"pagination":["157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10691013"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process of inflammation-related dysfunction of energy metabolism. Jieduan-Niwan formula (JDNWF) is a eutherapeutic Chinese medicine formula for ACLF. However, the intrinsic mechanism of its anti-ACLF effect still need to be studied systematically.<h4>Purpose</h4>This study aimed to investigate the mechanism of JDNWF against ACLF based on altered substance metabolic profile in ACLF the expression levels of related molecules.<h4>Materials and methods</h4>The chemical characteristics of JDNWF were characterized using ultra performance liquid chromatography (UPLC) coupled with triple quadrupole mass spectrometry. Wistar rats subjected to a long-te"],"journal":["Chinese medicine"],"pubmed_title":["Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle."],"pmcid":["PMC10691013"],"funding_grant_id":["82074237","2018YFC1704102","JJ-2020-51"],"pubmed_authors":["Ma R","Liang J","Gao Y","Wei X","Du Y","Wang H","Zhang Q","Hou W"],"additional_accession":[]},"is_claimable":false,"name":"Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.","description":"<h4>Background</h4>Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process of inflammation-related dysfunction of energy metabolism. Jieduan-Niwan formula (JDNWF) is a eutherapeutic Chinese medicine formula for ACLF. However, the intrinsic mechanism of its anti-ACLF effect still need to be studied systematically.<h4>Purpose</h4>This study aimed to investigate the mechanism of JDNWF against ACLF based on altered substance metabolic profile in ACLF the expression levels of related molecules.<h4>Materials and methods</h4>The chemical characteristics of JDNWF were characterized using ultra performance liquid chromatography (UPLC) coupled with triple quadrupole mass spectrometry. Wistar rats subjected to a long-te","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-05T11:45:12.471Z","creation":"2025-04-05T11:45:12.471Z"},"accession":"S-EPMC10691013","cross_references":{"pubmed":["38037150"],"doi":["10.1186/s13020-023-00858-x"]}}