{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28"],"submitter":["Ehrbar S"],"pubmed_abstract":["Radiotherapy in expiration breath-hold (EBH) has the potential to reduce treatment volumes of abdominal targets compared to an internal target volume concept in free-breathing. The reproducibility of EBH and required safety margins were investigated to quantify this volumetric benefit. Pre- and post-treatment diaphragm position difference and the positioning variability were determined on computed tomography. Systematic and random errors for EBH position reproducibility and positioning variability were calculated, resulting in margins of 7 to 12 mm depending on the prescription isodose and fractionation. A reduced volume was shown for EBH for lesions with superior-inferior breathing motion above 4 to 8 mm."],"journal":["Physics and imaging in radiation oncology"],"pagination":["100509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10692905"],"repository":["biostudies-literature"],"pubmed_title":["Intra- and inter-fraction breath-hold variations and margins for radiotherapy of abdominal targets."],"pmcid":["PMC10692905"],"pubmed_authors":["Perryck S","Moreira A","Andratschke N","Ehrbar S","Pavic M","Schrader M","Garcia Schuler H","Marvaso G","Guckenberger M","Van Timmeren JE","Tanadini-Lang S"],"additional_accession":[]},"is_claimable":false,"name":"Intra- and inter-fraction breath-hold variations and margins for radiotherapy of abdominal targets.","description":"Radiotherapy in expiration breath-hold (EBH) has the potential to reduce treatment volumes of abdominal targets compared to an internal target volume concept in free-breathing. The reproducibility of EBH and required safety margins were investigated to quantify this volumetric benefit. Pre- and post-treatment diaphragm position difference and the positioning variability were determined on computed tomography. Systematic and random errors for EBH position reproducibility and positioning variability were calculated, resulting in margins of 7 to 12 mm depending on the prescription isodose and fractionation. A reduced volume was shown for EBH for lesions with superior-inferior breathing motion above 4 to 8 mm.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-05T11:45:45.427Z","creation":"2025-04-05T11:45:45.427Z"},"accession":"S-EPMC10692905","cross_references":{"pubmed":["38045640"],"doi":["10.1016/j.phro.2023.100509"]}}