{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ng C"],"funding":["HHS | National Institutes of Health","NIAMS NIH HHS"],"pagination":["1340-1347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10693321"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["211(9)"],"pubmed_abstract":["TNF plays a crucial role in inflammation and bone resorption in various inflammatory diseases, including rheumatoid arthritis (RA). However, its direct ability to drive macrophages to differentiate into osteoclasts is limited. Although RBP-J is recognized as a key inhibitor of TNF-mediated osteoclastogenesis, the precise mechanisms that restrain TNF-induced differentiation of macrophages into osteoclasts are not fully elucidated. In this study, we identified that the Notch ligand Jagged1 is a previously unrecognized RBP-J target. The expression of Jagged1 is significantly induced by TNF mainly through RBP-J. The TNF-induced Jagged1 in turn functions as a feedback inhibitory regulator of TNF-mediated osteoclastogenesis. This feedback inhibition of osteoclastogenesis by Jagged1 does not exis"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis."],"pmcid":["PMC10693321"],"funding_grant_id":["R01 AR071463","R01 AR068970","AR078212","AR068970","AR071463","R01 AR078212"],"pubmed_authors":["Xia Y","Zhao B","Hu X","Ng C","Qin Y"],"additional_accession":[]},"is_claimable":false,"name":"Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis.","description":"TNF plays a crucial role in inflammation and bone resorption in various inflammatory diseases, including rheumatoid arthritis (RA). However, its direct ability to drive macrophages to differentiate into osteoclasts is limited. Although RBP-J is recognized as a key inhibitor of TNF-mediated osteoclastogenesis, the precise mechanisms that restrain TNF-induced differentiation of macrophages into osteoclasts are not fully elucidated. In this study, we identified that the Notch ligand Jagged1 is a previously unrecognized RBP-J target. The expression of Jagged1 is significantly induced by TNF mainly through RBP-J. The TNF-induced Jagged1 in turn functions as a feedback inhibitory regulator of TNF-mediated osteoclastogenesis. This feedback inhibition of osteoclastogenesis by Jagged1 does not exis","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T01:02:27.372Z","creation":"2025-04-04T01:02:27.372Z"},"accession":"S-EPMC10693321","cross_references":{"pubmed":["37756541"],"doi":["10.4049/jimmunol.2300317"]}}