biostudies-literatureUnknown13Raters VM<h4>Background</h4>Staging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated combined molecular markers to predict prognosis.<h4>Patients and methods</h4>890 tumor tissue samples were obtained from patients who underwent surgery for esophageal adenocarcinoma with curative intent. These were stained by tissue micro array for 48 markers which are associated with tumorigenesis and correlated with clinical data (TNM-staging, overall survival) by multivariate Cox regression.<h4>Results</h4>Two markers (preserved Y chromosome and high grade of (CD3+) T-cell infiltration) were found to be significantly and independently associated with better overall survival. We formed a score (called CY score) from the twoFrontiers in oncology1249172https://www.ebi.ac.uk/biostudies/studies/S-EPMC10693404biostudies-literatureCombined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma.PMC10693404Gebauer FLoser HSchroder WZander TRaters VMQuaas ABruns CFuchs HSchlosser HAfalseCombined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma.<h4>Background</h4>Staging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated combined molecular markers to predict prognosis.<h4>Patients and methods</h4>890 tumor tissue samples were obtained from patients who underwent surgery for esophageal adenocarcinoma with curative intent. These were stained by tissue micro array for 48 markers which are associated with tumorigenesis and correlated with clinical data (TNM-staging, overall survival) by multivariate Cox regression.<h4>Results</h4>Two markers (preserved Y chromosome and high grade of (CD3+) T-cell infiltration) were found to be significantly and independently associated with better overall survival. We formed a score (called CY score) from the two2023-01-01T00:00:00Z20232025-04-25T17:32:53.893Z2025-04-06T04:42:38.456ZS-EPMC106934043804500110.3389/fonc.2023.1249172