biostudies-literatureUnknown64(2)Kageyama SGerman Foundation of Heart Research<h4>Objectives</h4>The very long-term mortality of off-pump and on-pump coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in a randomized complex coronary artery disease population is unknown. This study aims to investigate the impact of on-pump and off-pump CABG versus PCI on 10-year all-cause mortality.<h4>Methods</h4>The SYNTAX trial randomized 1800 patients with three-vessel and/or left main coronary artery disease to PCI or CABG and assessed their survival at 10 years. In this sub-study, the hazard of mortality over 10 years was compared according to the technique of revascularization: on-pump CABG (n = 725), off-pump CABG (n = 128) and PCI (n = 903).<h4>Results</h4>There was substantial inter-site variation in the use of off-pump CABG despite baseline characteristics being largely homogeneous among the 3 groups. The crude rate of mortality was significantly lower following on-pump CABG versus PCI [25.6% vs 28.4%, hazard ratio (HR) 0.79, 95% confidence interval (CI) 0.65-0.96], while it was comparable between off-pump CABG and PCI (28.5% vs 28.4%, HR 0.98, 95% CI 0.69-1.40). After adjusting for the 9 variables included in the SYNTAX score II 2020, 10-year mortality remained significantly lower with on-pump CABG than PCI (HR 0.75 against PCI, P = 0.009).<h4>Conclusions</h4>In the SYNTAXES trial, 10-year mortality adjusted for major confounders was significantly lower following on-pump CABG compared to PCI. There was no evidence for unadjusted difference between off-pump CABG and PCI, although the unadjusted estimated HR had a wide CI. Site heterogeneity in the technique used in bypass surgery has had measurable effects on treatment performance.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgeryezad240https://www.ebi.ac.uk/biostudies/studies/S-EPMC10693439biostudies-literatureImpact of on-pump and off-pump coronary artery bypass grafting on 10-year mortality versus percutaneous coronary intervention.PMC10693439Stahle EHagl CDarremont ONabauer MSerruys PWMilojevic MSabate MThourani VBanning ASoo ASYNTAX Extended Survival InvestigatorsOldroyd KCoelho PJames SSpolaor Ade Bruyne BHoppe ULucas Svan Geuns RJAhlsson AStangl KKramer RColombo ASuryapranata HNoack TCannon LMacCarthy PSzerafin TEscaned JRuiz-Nodar JMDavierwala PMBuckner JKStark CLaine MRedwood SBurzotta FOnuma YKageyama SMack MJBochenek AO'Leary NWolschleger KGuagliumi GPreda IZelman RBerland Jde Belder AMasuda SCarrie DFeldman TAschermann Mden Heijer PEltchaninoff HStoler RWitkowski ATalbott JDKiesz STaussig ABerti SAkins CWCurzen NOlivecrona GNasseri BVermeersch PCanosi UNarbute ICasselman FKolh PMcGarry TLeGrand VGuera RMariani MAKnight CBarber KGrubitzsch HStine RAGonzalez ICLang IChristiansen EHZijlstra FEndresen KGarg SDavierwala PHeyrich GKotoku NBerg GBurke NBentala MHolmes DRGershlick AHo PCVerberkmoes NKrauze ADrieghe BNinomiya KHauptman KEAkca FKillinger WMorice MCChieffo AMooney MSandner SBogers AJeppsson AHeiser JHorwitz PAStefanini GGuber MSChen JCIngemansson RSchultz WGora Bvan der Harst PDudek DHorvath IReichenspurner HBilfinger TTchetche DGrothusen CEnsminger SBeyersdorf FLaufer GCorbascio MJan Suttorp MAccola KfalseImpact of on-pump and off-pump coronary artery bypass grafting on 10-year mortality versus percutaneous coronary intervention.<h4>Objectives</h4>The very long-term mortality of off-pump and on-pump coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in a randomized complex coronary artery disease population is unknown. This study aims to investigate the impact of on-pump and off-pump CABG versus PCI on 10-year all-cause mortality.<h4>Methods</h4>The SYNTAX trial randomized 1800 patients with three-vessel and/or left main coronary artery disease to PCI or CABG and assessed their survival at 10 years. In this sub-study, the hazard of mortality over 10 years was compared according to the technique of revascularization: on-pump CABG (n = 725), off-pump CABG (n = 128) and PCI (n = 903).<h4>Results</h4>There was substantial inter-site variation in the use of off-pump CABG despite baseline characteristics being largely homogeneous among the 3 groups. The crude rate of mortality was significantly lower following on-pump CABG versus PCI [25.6% vs 28.4%, hazard ratio (HR) 0.79, 95% confidence interval (CI) 0.65-0.96], while it was comparable between off-pump CABG and PCI (28.5% vs 28.4%, HR 0.98, 95% CI 0.69-1.40). After adjusting for the 9 variables included in the SYNTAX score II 2020, 10-year mortality remained significantly lower with on-pump CABG than PCI (HR 0.75 against PCI, P = 0.009).<h4>Conclusions</h4>In the SYNTAXES trial, 10-year mortality adjusted for major confounders was significantly lower following on-pump CABG compared to PCI. There was no evidence for unadjusted difference between off-pump CABG and PCI, although the unadjusted estimated HR had a wide CI. Site heterogeneity in the technique used in bypass surgery has had measurable effects on treatment performance.2023-01-01T00:00:00Z2023 Aug2026-06-12T05:27:57.304Z2025-04-04T19:00:25.828ZS-EPMC106934393734885710.1093/ejcts/ezad240