{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tong MZ"],"funding":["La Trobe University","National Health and Medical Research Council"],"pagination":["e1476"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10693902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["<h4>Objective</h4>Class III obesity (body mass index [BMI] ≥ 40 kg m<sup>-2</sup>) significantly impairs the immune response to SARS-CoV-2 vaccination. However, the effect of an elevated BMI (≥ 25 kg m<sup>-2</sup>) on humoral immunity to SARS-CoV-2 infection and COVID-19 vaccination remains unclear.<h4>Methods</h4>We collected blood samples from people who recovered from SARS-CoV-2 infection approximately 3 and 13 months of post-infection (noting that these individuals were not exposed to SARS-CoV-2 or vaccinated in the interim). We also collected blood samples from people approximately 5 months of post-second dose COVID-19 vaccination (the majority of whom did not have a prior SARS-CoV-2 infection). We measured their humoral responses to SARS-CoV-2, grouping individuals based on a BMI greater or less than 25 kg m<sup>-2</sup>.<h4>Results</h4>Here, we show that an increased BMI (≥ 25 kg m<sup>-2</sup>), when accounting for age and sex differences, is associated with reduced antibody responses after SARS-CoV-2 infection. At 3 months of post-infection, an elevated BMI was associated with reduced antibody titres. At 13 months of post-infection, an elevated BMI was associated with reduced antibody avidity and a reduced percentage of spike-positive B cells. In contrast, no significant association was noted between a BMI ≥ 25 kg m<sup>-2</sup> and humoral immunity to SARS-CoV-2 at 5 months of post-secondary vaccination.<h4>Conclusions</h4>Taken together, these data showed that elevated BMI is associated with an impaired humoral immune response to SARS-CoV-2 infection. The impairment of infection-induced immunity in individuals with a BMI ≥ 25 kg m<sup>-2</sup> suggests an added impetus for vaccination rather than relying on infection-induced immunity."],"journal":["Clinical & translational immunology"],"pubmed_title":["Elevated BMI reduces the humoral response to SARS-CoV-2 infection."],"pmcid":["PMC10693902"],"funding_grant_id":["2007919"],"pubmed_authors":["Cooper L","Gallo LA","Dorey ES","Collins N","Jayasinghe D","Barrett HL","Short KR","Smith C","Muller DA","Chew KY","Carney M","Tong MZ","Gras S","Joyce BA","Good-Jacobson K","Sng JD","Airey M","Ignacio K","Burr L","Lineburg KE","McMillan CL","Brown S","Adhikari A"],"additional_accession":[]},"is_claimable":false,"name":"Elevated BMI reduces the humoral response to SARS-CoV-2 infection.","description":"<h4>Objective</h4>Class III obesity (body mass index [BMI] ≥ 40 kg m<sup>-2</sup>) significantly impairs the immune response to SARS-CoV-2 vaccination. However, the effect of an elevated BMI (≥ 25 kg m<sup>-2</sup>) on humoral immunity to SARS-CoV-2 infection and COVID-19 vaccination remains unclear.<h4>Methods</h4>We collected blood samples from people who recovered from SARS-CoV-2 infection approximately 3 and 13 months of post-infection (noting that these individuals were not exposed to SARS-CoV-2 or vaccinated in the interim). We also collected blood samples from people approximately 5 months of post-second dose COVID-19 vaccination (the majority of whom did not have a prior SARS-CoV-2 infection). We measured their humoral responses to SARS-CoV-2, grouping individuals based on a BMI greater or less than 25 kg m<sup>-2</sup>.<h4>Results</h4>Here, we show that an increased BMI (≥ 25 kg m<sup>-2</sup>), when accounting for age and sex differences, is associated with reduced antibody responses after SARS-CoV-2 infection. At 3 months of post-infection, an elevated BMI was associated with reduced antibody titres. At 13 months of post-infection, an elevated BMI was associated with reduced antibody avidity and a reduced percentage of spike-positive B cells. In contrast, no significant association was noted between a BMI ≥ 25 kg m<sup>-2</sup> and humoral immunity to SARS-CoV-2 at 5 months of post-secondary vaccination.<h4>Conclusions</h4>Taken together, these data showed that elevated BMI is associated with an impaired humoral immune response to SARS-CoV-2 infection. The impairment of infection-induced immunity in individuals with a BMI ≥ 25 kg m<sup>-2</sup> suggests an added impetus for vaccination rather than relying on infection-induced immunity.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-29T07:37:54.851Z","creation":"2025-02-19T01:16:17.626Z"},"accession":"S-EPMC10693902","cross_references":{"pubmed":["38050635"],"doi":["10.1002/cti2.1476"]}}