{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Strikic A"],"pubmed_abstract":["Renal cell carcinoma (RCC) represents around 3% of all cancers, with the most frequent histological types being clear-cell RCC (ccRCC), followed by papillary (pRCC) and chromophobe (chRCC). Hypoxia-inducible factors (HIFs), which promote the expression of various target genes, including vascular endothelial growth factor (VEGF) and the high- affinity glucose transporter 1, have an important role in the pathogenesis of RCC. This study investigated the immunohistochemical expression of HIF-1α and VEGF-A, showing significantly higher HIF-1α nuclear expression in pRCC compared to ccRCC, while there was no significant difference in VEGF-A protein expression between the analyzed histological RCC subtypes. The quantitative reverse transcription polymerase chain reaction for <i>HIF1A</i> showed no statistical difference between histological types. Data from publicly available RNA sequencing databases were analyzed and showed that, compared to healthy kidney tissue, <i>VEGFA</i> was significantly up-regulated in ccRCC and significantly down-regulated in pRCC. The comparison between histological subtypes of RCC revealed that <i>VEGFA</i> was significantly up-regulated in ccRCC compared to both pRCC and chRCC. There was no statistically significant difference in survival time between <i>HIF1A</i> high- and low-expression groups of patients. As for <i>VEGFA</i> expression, pRCC patients with low expression had a significantly higher survival rate compared to patients with high <i>VEGFA</i> expression."],"journal":["Frontiers in oncology"],"pagination":["1287239"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10694430"],"repository":["biostudies-literature"],"pubmed_title":["Differential expression of <i>HIF1A</i> and its downstream target <i>VEGFA</i> in the main subtypes of renal cell carcinoma and their impact on patient survival."],"pmcid":["PMC10694430"],"pubmed_authors":["Kelam N","Tomas SZ","Dolonga P","Kokeza J","Vukoja M","Ogorevc M","Strikic A"],"additional_accession":[]},"is_claimable":false,"name":"Differential expression of <i>HIF1A</i> and its downstream target <i>VEGFA</i> in the main subtypes of renal cell carcinoma and their impact on patient survival.","description":"Renal cell carcinoma (RCC) represents around 3% of all cancers, with the most frequent histological types being clear-cell RCC (ccRCC), followed by papillary (pRCC) and chromophobe (chRCC). Hypoxia-inducible factors (HIFs), which promote the expression of various target genes, including vascular endothelial growth factor (VEGF) and the high- affinity glucose transporter 1, have an important role in the pathogenesis of RCC. This study investigated the immunohistochemical expression of HIF-1α and VEGF-A, showing significantly higher HIF-1α nuclear expression in pRCC compared to ccRCC, while there was no significant difference in VEGF-A protein expression between the analyzed histological RCC subtypes. The quantitative reverse transcription polymerase chain reaction for <i>HIF1A</i> showed no statistical difference between histological types. Data from publicly available RNA sequencing databases were analyzed and showed that, compared to healthy kidney tissue, <i>VEGFA</i> was significantly up-regulated in ccRCC and significantly down-regulated in pRCC. The comparison between histological subtypes of RCC revealed that <i>VEGFA</i> was significantly up-regulated in ccRCC compared to both pRCC and chRCC. There was no statistically significant difference in survival time between <i>HIF1A</i> high- and low-expression groups of patients. As for <i>VEGFA</i> expression, pRCC patients with low expression had a significantly higher survival rate compared to patients with high <i>VEGFA</i> expression.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-05-18T11:51:33.96Z","creation":"2025-05-18T11:51:33.96Z"},"accession":"S-EPMC10694430","cross_references":{"pubmed":["38053655"],"doi":["10.3389/fonc.2023.1287239"]}}