{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sponaugle A"],"funding":["NIAID NIH HHS","NCI NIH HHS","National Institutes of Health"],"pagination":["101268"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10694675"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(11)"],"pubmed_abstract":["In people with HIV (PWH), the post-antiretroviral therapy (ART) window is critical for immune restoration and HIV reservoir stabilization. We employ deep immune profiling and T cell receptor (TCR) sequencing and examine proliferation to assess how ART impacts T cell homeostasis. In PWH on long-term ART, lymphocyte frequencies and phenotypes are mostly stable. By contrast, broad phenotypic changes in natural killer (NK) cells, γδ T cells, B cells, and CD4<sup>+</sup> and CD8<sup>+</sup> T cells are observed in the post-ART window. Whereas CD8<sup>+</sup> T cells mostly restore, memory CD4<sup>+</sup> T subsets and cytolytic NK cells show incomplete restoration 1.4 years post ART. Surprisingly, the hierarchies and frequencies of dominant CD4 TCR clonotypes (0.1%-11% of all CD4<sup>+</sup> T cells) remain stable post ART, suggesting that clonal homeostasis can be independent of homeostatic processes regulating CD4<sup>+</sup> T cell absolute number, phenotypes, and function. The slow restoration of host immunity post ART also has implications for the design of ART interruption studies."],"journal":["Cell reports. Medicine"],"pubmed_title":["Dominant CD4<sup>+</sup> T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV."],"pmcid":["PMC10694675"],"funding_grant_id":["R37 CA247676","UM1 AI069423","P30 AI050410","UM1 AI106701","UM1 AI164567","P30 CA016086","UM1 AI068634","5UM1AI164567","UM1AI106701-08"],"pubmed_authors":["Hudgens MG","Archin NM","Vincent BG","Sponaugle A","Adimora AA","Weideman AMK","Stanley N","Ranek J","Atassi G","Kuritzkes DR","Eron JJ","Margolis DM","Gay C","Kuruc J","Goonetilleke N"],"additional_accession":[]},"is_claimable":false,"name":"Dominant CD4<sup>+</sup> T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV.","description":"In people with HIV (PWH), the post-antiretroviral therapy (ART) window is critical for immune restoration and HIV reservoir stabilization. We employ deep immune profiling and T cell receptor (TCR) sequencing and examine proliferation to assess how ART impacts T cell homeostasis. In PWH on long-term ART, lymphocyte frequencies and phenotypes are mostly stable. By contrast, broad phenotypic changes in natural killer (NK) cells, γδ T cells, B cells, and CD4<sup>+</sup> and CD8<sup>+</sup> T cells are observed in the post-ART window. Whereas CD8<sup>+</sup> T cells mostly restore, memory CD4<sup>+</sup> T subsets and cytolytic NK cells show incomplete restoration 1.4 years post ART. Surprisingly, the hierarchies and frequencies of dominant CD4 TCR clonotypes (0.1%-11% of all CD4<sup>+</sup> T cells) remain stable post ART, suggesting that clonal homeostasis can be independent of homeostatic processes regulating CD4<sup>+</sup> T cell absolute number, phenotypes, and function. The slow restoration of host immunity post ART also has implications for the design of ART interruption studies.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-17T06:40:38.462Z","creation":"2025-04-19T17:02:50.769Z"},"accession":"S-EPMC10694675","cross_references":{"pubmed":["37949070"],"doi":["10.1016/j.xcrm.2023.101268"]}}