{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Booyse RP"],"funding":["NIH/NHGRI","NHGRI NIH HHS","University of the Witwatersrand","Sydney Brenner Charitable Trust"],"pagination":["845-857"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10694788"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(16)"],"pubmed_abstract":["<b>Background:</b> <i>CYP2C19</i> is important in the metabolism of clopidogrel and several antidepressants. This study aimed to characterize the distribution of <i>CYP2C19</i> star alleles (haplotypes) across diverse African populations compared with global populations. <b>Methods:</b> <i>CYP2C19</i> star alleles and diplotypes were called from high coverage genomes using the StellarPGx pipeline. <b>Results:</b> <i>CYP2C19*1</i> (51%), <i>*2</i> (17%) and <i>*17</i> (22%) were the most common star alleles across African populations in this study. It was observed that 3% of African participants had potentially novel <i>CYP2C19</i> haplotypes. <b>Conclusion:</b> This study supports the necessity for <i>CYP2C19</i> pharmacogenetic testing in African and global clinical settings, as well as t"],"journal":["Pharmacogenomics"],"pubmed_title":["Characterization of <i>CYP2C19</i> pharmacogenetic variation in African populations and comparison with other global populations."],"pmcid":["PMC10694788"],"funding_grant_id":["UM1 HG008901","U54 HG006938","U54HG006938"],"pubmed_authors":["Twesigomwe D","Hazelhurst S","Booyse RP"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of <i>CYP2C19</i> pharmacogenetic variation in African populations and comparison with other global populations.","description":"<b>Background:</b> <i>CYP2C19</i> is important in the metabolism of clopidogrel and several antidepressants. This study aimed to characterize the distribution of <i>CYP2C19</i> star alleles (haplotypes) across diverse African populations compared with global populations. <b>Methods:</b> <i>CYP2C19</i> star alleles and diplotypes were called from high coverage genomes using the StellarPGx pipeline. <b>Results:</b> <i>CYP2C19*1</i> (51%), <i>*2</i> (17%) and <i>*17</i> (22%) were the most common star alleles across African populations in this study. It was observed that 3% of African participants had potentially novel <i>CYP2C19</i> haplotypes. <b>Conclusion:</b> This study supports the necessity for <i>CYP2C19</i> pharmacogenetic testing in African and global clinical settings, as well as t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-02T04:01:18.134Z","creation":"2025-04-06T00:58:35.52Z"},"accession":"S-EPMC10694788","cross_references":{"pubmed":["37929326"],"doi":["10.2217/pgs-2023-0166"]}}