{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Batista LAS"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pagination":["e39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10695728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(4)"],"pubmed_abstract":["<h4>Objectives</h4>This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.<h4>Materials and methods</h4>Electronic searches were performed in July 2023. <i>In vivo</i> and <i>in vitro</i> studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.<h4>Results</h4>Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%-38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or"],"journal":["Restorative dentistry & endodontics"],"pubmed_title":["Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research."],"pmcid":["PMC10695728"],"funding_grant_id":["128044/2022-5","88887.649870/2021-00","88887.712700/2022-00"],"pubmed_authors":["Dos Reis-Prado AH","Chaves HGDS","Andre CB","Suzuki TY","Batista LAS","Morgan LFSA","de Arantes LC","Benetti F"],"additional_accession":[]},"is_claimable":false,"name":"Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research.","description":"<h4>Objectives</h4>This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.<h4>Materials and methods</h4>Electronic searches were performed in July 2023. <i>In vivo</i> and <i>in vitro</i> studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.<h4>Results</h4>Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%-38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-03T08:06:39.445Z","creation":"2026-04-26T03:11:23.433Z"},"accession":"S-EPMC10695728","cross_references":{"pubmed":["38053785"],"doi":["10.5395/rde.2023.48.e39"]}}