biostudies-literatureBatista LASConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superiore39https://www.ebi.ac.uk/biostudies/studies/S-EPMC10695728biostudies-literatureUnknown48(4)<h4>Objectives</h4>This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.<h4>Materials and methods</h4>Electronic searches were performed in July 2023. <i>In vivo</i> and <i>in vitro</i> studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.<h4>Results</h4>Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%-38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass orRestorative dentistry & endodonticsCan different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research.PMC10695728128044/2022-588887.649870/2021-0088887.712700/2022-00Dos Reis-Prado AHChaves HGDSAndre CBSuzuki TYBatista LASMorgan LFSAde Arantes LCBenetti FfalseCan different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research.<h4>Objectives</h4>This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.<h4>Materials and methods</h4>Electronic searches were performed in July 2023. <i>In vivo</i> and <i>in vitro</i> studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.<h4>Results</h4>Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%-38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or2023-01-01T00:00:00Z2023 Nov2026-06-03T08:06:39.445Z2026-04-26T03:11:23.433ZS-EPMC106957283805378510.5395/rde.2023.48.e39