biostudies-literatureArmstrong NMIntramural NIH HHSNIA NIH HHSNational Institute of Nursing ResearchNINR NIH HHSNational Institutes of HealthNational Institute on Aging114-122https://www.ebi.ac.uk/biostudies/studies/S-EPMC10696594biostudies-literatureUnknown317<h4>Objective</h4>We explored the associations of dual sensory impairment (DSI) with long-term depressive and anxiety symptoms as well as low perceived social support (LPSS) as a modifier of these associations.<h4>Methods</h4>Multinomial logistic regression models were used to examine the associations of DSI and single sensory impairment (hearing [pure-tone average > 25 dB] and vision [impaired visual acuity and/or contrast sensitivity]) with long-term depressive symptom (≥8 on the 10-item Center for Epidemiologic Studies-Depression Scale) and anxiety symptom (present on the Hopkins Symptom Checklist) latent classes from group-based trajectory models (rare/never; mild/moderate increasing; chronically high) among 2102 Health, Aging and Body Composition Study participants (mean age:74.0 ± 2.8 years; 51.9 % female) over 10 years. Models were adjusted by demographic characteristics and cardiovascular risk factors, and LPSS. An additional model evaluated the two-way interaction between DSI and LPSS.<h4>Results</h4>DSI was associated with increased risk of being chronically depressed (Risk Ratio, RR = 1.99, 95 % Confidence Interval, CI: 1.25, 3.17), not mild/moderate increasingly depressed (RR = 1.25, 95 % CI: 0.91, 1.71). DSI had increased risk of being mild/moderate increasingly anxious (RR = 1.60, 95 % CI: 1.16, 2.19) and chronically anxious (RR = 1.86, 95 % CI: 1.05, 3.27) groups, as compared to no impairments. Hearing impairment was associated with being mild/moderate increasingly anxious (RR = 1.34, 95 % CI: 1.01, 1.79). No other associations were found for single sensory impairments. LPSS did not modify associations.<h4>Limitations</h4>Sensory measures were time-fixed, and LPSS, depression and anxiety measures were self-reported.<h4>Conclusions</h4>Future research is warranted to determine if DSI therapies may lessen long-term chronically high depressive and anxiety symptoms.Journal of affective disordersAssociations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States.PMC10696594K01AG054693K01AG062722R01 AG028050K01 AG054693N01-AG-6-2106R01 NR012459K01 AG062722R01-AG028050N01-AG-6-2101Z99 AG999999R01-NR012459R01-AG-6-2103Swenor BLin FRDeal JASimonsick EMPowell DSJones RNArmstrong NMBrenowitz WDVieira Ligo Teixeira CGendron CfalseAssociations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States.<h4>Objective</h4>We explored the associations of dual sensory impairment (DSI) with long-term depressive and anxiety symptoms as well as low perceived social support (LPSS) as a modifier of these associations.<h4>Methods</h4>Multinomial logistic regression models were used to examine the associations of DSI and single sensory impairment (hearing [pure-tone average > 25 dB] and vision [impaired visual acuity and/or contrast sensitivity]) with long-term depressive symptom (≥8 on the 10-item Center for Epidemiologic Studies-Depression Scale) and anxiety symptom (present on the Hopkins Symptom Checklist) latent classes from group-based trajectory models (rare/never; mild/moderate increasing; chronically high) among 2102 Health, Aging and Body Composition Study participants (mean age:74.0 ± 2.8 years; 51.9 % female) over 10 years. Models were adjusted by demographic characteristics and cardiovascular risk factors, and LPSS. An additional model evaluated the two-way interaction between DSI and LPSS.<h4>Results</h4>DSI was associated with increased risk of being chronically depressed (Risk Ratio, RR = 1.99, 95 % Confidence Interval, CI: 1.25, 3.17), not mild/moderate increasingly depressed (RR = 1.25, 95 % CI: 0.91, 1.71). DSI had increased risk of being mild/moderate increasingly anxious (RR = 1.60, 95 % CI: 1.16, 2.19) and chronically anxious (RR = 1.86, 95 % CI: 1.05, 3.27) groups, as compared to no impairments. Hearing impairment was associated with being mild/moderate increasingly anxious (RR = 1.34, 95 % CI: 1.01, 1.79). No other associations were found for single sensory impairments. LPSS did not modify associations.<h4>Limitations</h4>Sensory measures were time-fixed, and LPSS, depression and anxiety measures were self-reported.<h4>Conclusions</h4>Future research is warranted to determine if DSI therapies may lessen long-term chronically high depressive and anxiety symptoms.2022-01-01T00:00:00Z2022 Nov2025-04-22T07:59:11.211Z2025-04-05T22:25:08.407ZS-EPMC106965943593294010.1016/j.jad.2022.07.067