biostudies-literatureLin KYScience and Technology Innovation Joint Foundation of Fujian ProvinceFujian Medical University Qihang Fund Graduate Innovation ProjectNational Natural Science Foundation of ChinaMajor Research Projects for Young and Middle-aged Researchers of Fujian Provincial Health Care Commission1190https://www.ebi.ac.uk/biostudies/studies/S-EPMC10696803biostudies-literatureUnknown23(1)<h4>Background</h4>Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit from the inclusion of tumor biological marker alpha-fetoprotein (AFP) and systemic inflammation indicator C-reactive protein (CRP).<h4>Methods</h4>Data from a multicenter cohort of 2770 HCC patients undergoing hepatectomy were analyzed. We developed the PACE risk score (Prognostic implications of AFP and CRP Elevation) after initially assessing preoperative AFP and CRP's prognostic value. Subgroup analyzes were performed in BCLC cohorts A and B using multivariable Cox analysis to evaluate the prognostic stratification ability of the PACE risk score and its complementBMC cancerPrognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients.PMC106968032022QH20302021ZQNZD013622750502019Y9108Li YTZheng SMZheng LFTang SCLin ZWYou PHLin KCChen QJWang XMLin KYZhang JXFu JZeng YYYang TWu MMLu QGuo LBZhou WPfalsePrognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients.<h4>Background</h4>Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit from the inclusion of tumor biological marker alpha-fetoprotein (AFP) and systemic inflammation indicator C-reactive protein (CRP).<h4>Methods</h4>Data from a multicenter cohort of 2770 HCC patients undergoing hepatectomy were analyzed. We developed the PACE risk score (Prognostic implications of AFP and CRP Elevation) after initially assessing preoperative AFP and CRP's prognostic value. Subgroup analyzes were performed in BCLC cohorts A and B using multivariable Cox analysis to evaluate the prognostic stratification ability of the PACE risk score and its complement2023-01-01T00:00:00Z2023 Dec2025-04-22T20:12:02.451Z2024-10-18T07:31:00.424ZS-EPMC106968033805304810.1186/s12885-023-11693-6