{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jaffe AE"],"funding":["NIDA NIH HHS","NIMH NIH HHS"],"pagination":["673-686"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10697016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["179(9)"],"pubmed_abstract":["<h4>Objective</h4>Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The overlap in symptoms is hypothesized to stem from partially shared genetics and underlying neurobiological mechanisms. To delineate conservation between transcriptional patterns across PTSD and MDD, the authors examined gene expression in the human cortex and amygdala in these disorders.<h4>Methods</h4>RNA sequencing was performed in the postmortem brain of two prefrontal cortex regions and two amygdala regions from donors diagnosed with PTSD (N=107) or MDD (N=109) as well as from neurotypical donors (N=109).<h4>Results</h4>The authors identified a limited number of differentially expressed genes (DEGs) speci"],"journal":["The American journal of psychiatry"],"pubmed_title":["Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive Disorders."],"pmcid":["PMC10697016"],"funding_grant_id":["R01 MH105592","R01 DA053581"],"pubmed_authors":["Pattie EA","Friedman MJ","Bharadwaj R","Williamson DE","Traumatic Stress Brain Research Group","Kleinman JE","Nguyen CV","Maynard KR","Hyde TM","Martinowich K","Page SC","Shin JH","Tao R","Deep-Soboslay A","Jaffe AE","Young KA"],"additional_accession":[]},"is_claimable":false,"name":"Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive Disorders.","description":"<h4>Objective</h4>Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The overlap in symptoms is hypothesized to stem from partially shared genetics and underlying neurobiological mechanisms. To delineate conservation between transcriptional patterns across PTSD and MDD, the authors examined gene expression in the human cortex and amygdala in these disorders.<h4>Methods</h4>RNA sequencing was performed in the postmortem brain of two prefrontal cortex regions and two amygdala regions from donors diagnosed with PTSD (N=107) or MDD (N=109) as well as from neurotypical donors (N=109).<h4>Results</h4>The authors identified a limited number of differentially expressed genes (DEGs) speci","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T08:01:37.675Z","creation":"2025-04-05T22:24:40.676Z"},"accession":"S-EPMC10697016","cross_references":{"pubmed":["35791611"],"doi":["10.1176/appi.ajp.21020162"]}}