{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pulcrano S"],"funding":["HHS | NIH | National Institute of Mental Health","Telethon","NINDS NIH HHS","Ministero dell'Università e della Ricerca"],"pagination":["8104-8125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10697421"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(48)"],"pubmed_abstract":["In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic plasticity at a higher level by acting as an additional mechanism of translational regulation, alongside the mRNA/polysome system. Despite extensive research, our understanding of the specific contribution of individual miRNA to the function of dopaminergic neurons (DAn) remains limited. By performing a dopaminergic-specific miRNA screening, we have identified miR-218 as a critical regulator of DAn activity in male and female mice. We have found that miR-218 is specifically expressed in mesencephalic DAn and is able to promote dopaminergic differentiation of embryonic stem cells and functional maturation of transdifferentiated induced DA neurons. Midbrain-specific deletion of both genes encoding for miR-"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network."],"pmcid":["PMC10697421"],"funding_grant_id":["R01 NS119690","R01NS119690","TMDMMFU22TT","PRIN 2017T9JNLT_004"],"pubmed_authors":["Speranza L","Volpicelli F","Guatteo E","Pulcrano S","De Gregorio R","Perrone-Capano C","Piscitelli RM","Giacomet C","Mercuri NB","De Sanctis C","Martini A","Awatramani R","Federici M","di Porzio U","Caiazzo M","Medina D","Bellenchi GC","Viggiano D"],"additional_accession":[]},"is_claimable":false,"name":"miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.","description":"In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic plasticity at a higher level by acting as an additional mechanism of translational regulation, alongside the mRNA/polysome system. Despite extensive research, our understanding of the specific contribution of individual miRNA to the function of dopaminergic neurons (DAn) remains limited. By performing a dopaminergic-specific miRNA screening, we have identified miR-218 as a critical regulator of DAn activity in male and female mice. We have found that miR-218 is specifically expressed in mesencephalic DAn and is able to promote dopaminergic differentiation of embryonic stem cells and functional maturation of transdifferentiated induced DA neurons. Midbrain-specific deletion of both genes encoding for miR-","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-05-23T03:15:22.712Z","creation":"2026-05-23T03:08:06.248Z"},"accession":"S-EPMC10697421","cross_references":{"pubmed":["37816598"],"doi":["10.1523/jneurosci.0431-23.2023","10.1523/JNEUROSCI.0431-23.2023"]}}