{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kemter AM"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["113153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10697505"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(10)"],"pubmed_abstract":["The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c<sup>+</sup> antigen-presenting cells. AhR signaling in RORγt<sup>+</sup> cells is necessary for the induction of IL-22. Mice deficient in AhR in RORγt<sup>+</sup> cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic responses to food."],"journal":["Cell reports"],"pubmed_title":["Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food."],"pmcid":["PMC10697505"],"funding_grant_id":["R01 AI106302","R25 GM109439","R01 AI146099","P30 DK042086"],"pubmed_authors":["Patry RT","Arnold J","Mimee M","Campbell E","Wang S","Nagler CR","Hesser LA","Ionescu E","Kemter AM"],"additional_accession":[]},"is_claimable":false,"name":"Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.","description":"The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c<sup>+</sup> antigen-presenting cells. AhR signaling in RORγt<sup>+</sup> cells is necessary for the induction of IL-22. Mice deficient in AhR in RORγt<sup>+</sup> cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic responses to food.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-05-28T23:55:29.725Z","creation":"2024-10-18T06:31:53.642Z"},"accession":"S-EPMC10697505","cross_references":{"pubmed":["37742185"],"doi":["10.1016/j.celrep.2023.113153"]}}