{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112(12)"],"submitter":["Miro O"],"funding":["Instituto de Salud Carlos III","Universitat de Barcelona"],"pubmed_abstract":["<h4>Objective</h4>To investigate the association of corrected QT (QTc) interval duration and short-term outcomes in patients with acute heart failure (AHF).<h4>Methods</h4>We analyzed AHF patients enrolled in 11 Spanish emergency departments (ED) for whom an ECG with QTc measurement was available. Patients with pace-maker rhythm were excluded. Primary outcome was 30-day all-cause mortality and secondary outcomes were need of hospitalization, in-hospital mortality and prolonged hospitalization (> 7 days). Association between QTc and outcomes was explored by restricted cubic spline (RCS) curves. Results were expressed as odds ratios (OR) and 95%CI adjusted by patients baseline and decompensation characteristics, using a QTc = 450 ms as reference.<h4>Results</h4>Of 1800 patients meeting entry criteria (median age 84 years (IQR = 77-89), 56% female), their median QTc was 453 ms (IQR = 422-483). The 30-day mortality was 9.7%, while need of hospitalization, in-hospital mortality and prolonged hospitalization were 77.8%, 9.0% and 50.0%, respectively. RCS curves found longer QTc was associated with 30-day mortality if > 561 ms, OR = 1.86 (1.00-3.45), and increased up to OR = 10.5 (2.25-49.1), for QTc = 674 ms. A similar pattern was observed for in-hospital mortality; OR = 2.64 (1.04-6.69), for QTc = 588 ms, and increasing up to OR = 8.02 (1.30-49.3), for QTc = 674 ms. Conversely, the need of hospitalization had a U-shaped relationship: being increased in patients with shorter QTc [OR = 1.45 (1.00-2.09) for QTc = 381 ms, OR = 5.88 (1.25-27.6) for the shortest QTc of 200 ms], and also increasing for prolonged QTc [OR = 1.06 (1.00-1.13), for QTc = 459 ms, and reaching OR = 2.15 (1.00-4.62) for QTc = 588 ms]. QTc was not associated with prolonged hospitalization.<h4>Conclusion</h4>In ED AHF patients, initial QTc provides independent short-term prognostic information, with increasing QTc associated with increasing mortality, while both, shortened and prolonged QTc are associated with need of hospitalization."],"journal":["Clinical research in cardiology : official journal of the German Cardiac Society"],"pagination":["1754-1765"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10698082"],"repository":["biostudies-literature"],"pubmed_title":["QT interval and short-term outcome in acute heart failure."],"pmcid":["PMC10698082"],"pubmed_authors":["Sanchez Gonzalez M","Javaloyes P","Amores Arriaga B","Minguez Maso S","Llopis Garcia G","Llauger Garcia L","Alonso H","Garcia Garcia M","Calderon Jave LE","Comas P","Rodriguez Miranda B","Herrero-Puente P","Llauger L","Aguilo O","Aguera Urbano C","Mueller C","Aguirre A","Traveria Becquer L","Rafique Z","Aguilo S","Garcia Soto AB","Keene KR","Fuentes M","Perez-Llantada E","Adroher Munoz M","Gil A","Valero A","Alarcon Jimenez BS","Gil C","Peacock F","Lopez-Ayala P","Lorca Serralta MT","Juan MA","Herrera S","Pavon J","Pedragosa MA","Richard F","Pinera P","Roset A","Cabello I","Franco JM","Delgado Padial E","Berenguer M","Escoda R","Coma Casanova P","Martin Mojarro E","Sanchez C","Ruiz F","Gil V","Lopez-Diez MP","Rodriguez-Adrada E","Corominas LaSalle G","Sanchez Ramon S","Mont L","Gaya R","Trullas JC","Vazquez Alvarez J","Miro O","Nunez J","Mecina AB","Molina F","Lopez-Grima ML","Bibiano C","Mir M","Ruiz M","Garrido JM","Jacob J","Llorens P","Vicente Martin M","Alvarez Perez JM","Rizzi MA","Garcia T","Herrero Puente P","Espinosa B","Sierra Bergua B","Carbajosa Rodriguez V","Donea R","Millan J","Carballo JL","Montero Perez-Barquero M","Burillo G","Tost J","Rodriguez B","Andueza JA","Cadenas MS","Soy Ferrer E","Alonso MI","Romero R","Haro A","Prieto Garcia B","Lucas-Imbernon FJ","Martin-Sanchez FJ","Espinach Alvaros J","ICA-SEMES research investigators","Hernandez N","Sanchez Nicolas JA","Torres Garate R","Jimenez I","Calvache R","Noval A","Alquezar-Arbe A"],"additional_accession":[]},"is_claimable":false,"name":"QT interval and short-term outcome in acute heart failure.","description":"<h4>Objective</h4>To investigate the association of corrected QT (QTc) interval duration and short-term outcomes in patients with acute heart failure (AHF).<h4>Methods</h4>We analyzed AHF patients enrolled in 11 Spanish emergency departments (ED) for whom an ECG with QTc measurement was available. Patients with pace-maker rhythm were excluded. Primary outcome was 30-day all-cause mortality and secondary outcomes were need of hospitalization, in-hospital mortality and prolonged hospitalization (> 7 days). Association between QTc and outcomes was explored by restricted cubic spline (RCS) curves. Results were expressed as odds ratios (OR) and 95%CI adjusted by patients baseline and decompensation characteristics, using a QTc = 450 ms as reference.<h4>Results</h4>Of 1800 patients meeting entry criteria (median age 84 years (IQR = 77-89), 56% female), their median QTc was 453 ms (IQR = 422-483). The 30-day mortality was 9.7%, while need of hospitalization, in-hospital mortality and prolonged hospitalization were 77.8%, 9.0% and 50.0%, respectively. RCS curves found longer QTc was associated with 30-day mortality if > 561 ms, OR = 1.86 (1.00-3.45), and increased up to OR = 10.5 (2.25-49.1), for QTc = 674 ms. A similar pattern was observed for in-hospital mortality; OR = 2.64 (1.04-6.69), for QTc = 588 ms, and increasing up to OR = 8.02 (1.30-49.3), for QTc = 674 ms. Conversely, the need of hospitalization had a U-shaped relationship: being increased in patients with shorter QTc [OR = 1.45 (1.00-2.09) for QTc = 381 ms, OR = 5.88 (1.25-27.6) for the shortest QTc of 200 ms], and also increasing for prolonged QTc [OR = 1.06 (1.00-1.13), for QTc = 459 ms, and reaching OR = 2.15 (1.00-4.62) for QTc = 588 ms]. QTc was not associated with prolonged hospitalization.<h4>Conclusion</h4>In ED AHF patients, initial QTc provides independent short-term prognostic information, with increasing QTc associated with increasing mortality, while both, shortened and prolonged QTc are associated with need of hospitalization.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-26T11:47:12.585Z","creation":"2025-04-06T13:48:23.963Z"},"accession":"S-EPMC10698082","cross_references":{"pubmed":["37004527"],"doi":["10.1007/s00392-023-02173-9"]}}