{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Denolly S"],"funding":["European Research Council","Deutsche Forschungsgemeinschaft (German Research Foundation)"],"pagination":["8045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10698153"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes. Here, we isolate ER membranes from ZIKV-infected cells and determine their proteome. Forty-six host cell factors are enriched in ZIKV remodeled membranes, several of these having a role in redox and methylation pathways. Four proteins are characterized in detail: thioredoxin reductase 1 (TXNRD1) contributing to folding of disulfide bond containing proteins and modulating ZIKV secretion; aldo-keto reductase family 1 member C3 (AKR1C3), regulating capsid protein abundance and thus, ZIKV assembly; biliverdin reductase B (BLVRB) involved in ZIKV induced lipid peroxidation and incre"],"journal":["Nature communications"],"pubmed_title":["Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways."],"pmcid":["PMC10698153"],"funding_grant_id":["TRR179 (TP11))","817798","240245660-SFB1129","SPP2306","499982526-BA"],"pubmed_authors":["Rosinski AN","Kritsiligkou P","Joecks S","Dick TP","Stukalov A","Denolly S","Barayeu U","Pichlmair A","Bartenschlager R"],"additional_accession":[]},"is_claimable":false,"name":"Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways.","description":"Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes. Here, we isolate ER membranes from ZIKV-infected cells and determine their proteome. Forty-six host cell factors are enriched in ZIKV remodeled membranes, several of these having a role in redox and methylation pathways. Four proteins are characterized in detail: thioredoxin reductase 1 (TXNRD1) contributing to folding of disulfide bond containing proteins and modulating ZIKV secretion; aldo-keto reductase family 1 member C3 (AKR1C3), regulating capsid protein abundance and thus, ZIKV assembly; biliverdin reductase B (BLVRB) involved in ZIKV induced lipid peroxidation and incre","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-28T20:04:24.07Z","creation":"2024-11-06T04:59:56.512Z"},"accession":"S-EPMC10698153","cross_references":{"pubmed":["38052817"],"doi":["10.1038/s41467-023-43665-6"]}}