{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(23)"],"submitter":["Krimpenfort RA"],"pubmed_abstract":["E-cadherin is a crucial regulator of epithelial cell-to-cell adhesion and an established tumor suppressor. Aside epithelia, E-cadherin expression marks the erythroid cell lineage during human but not mouse hematopoiesis. However, the role of E-cadherin in human erythropoiesis remains unknown. Because rat erythropoiesis was postulated to reflect human erythropoiesis more closely than mouse erythropoiesis, we investigated E-cadherin expression in rat erythroid progenitors. E-cadherin expression is conserved within the erythroid lineage between rat and human. In response to anemia, erythroblasts in rat bone marrow (BM) upregulate E-cadherin as well as its binding partner β-catenin. CRISPR/Cas9-mediated knock out of E-cadherin revealed that E-cadherin expression is required to stabilize β-cate"],"journal":["Blood advances"],"pagination":["7169-7183"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10698263"],"repository":["biostudies-literature"],"pubmed_title":["E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis."],"pmcid":["PMC10698263"],"pubmed_authors":["von Lindern M","Krimpenfort RA","van der Meulen SA","Nethe M","Verhagen H","Filonova G","van den Akker E","Hoogenboezem M","Driessen M"],"additional_accession":[]},"is_claimable":false,"name":"E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis.","description":"E-cadherin is a crucial regulator of epithelial cell-to-cell adhesion and an established tumor suppressor. Aside epithelia, E-cadherin expression marks the erythroid cell lineage during human but not mouse hematopoiesis. However, the role of E-cadherin in human erythropoiesis remains unknown. Because rat erythropoiesis was postulated to reflect human erythropoiesis more closely than mouse erythropoiesis, we investigated E-cadherin expression in rat erythroid progenitors. E-cadherin expression is conserved within the erythroid lineage between rat and human. In response to anemia, erythroblasts in rat bone marrow (BM) upregulate E-cadherin as well as its binding partner β-catenin. CRISPR/Cas9-mediated knock out of E-cadherin revealed that E-cadherin expression is required to stabilize β-cate","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-25T17:19:05.837Z","creation":"2025-04-06T05:22:58.064Z"},"accession":"S-EPMC10698263","cross_references":{"pubmed":["37792794"],"doi":["10.1182/bloodadvances.2023010875"]}}