biostudies-literatureUnknown13(50)Luo ZPyrrolo[2,1-<i>a</i>]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes <i>via</i> an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process. This reaction was promoted by a four-component catalytic system which included [RuCl₂(<i>p</i>-cymene)]₂, CuCl, copper acetate monohydrate and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) under aerobic conditions.RSC advances35617-35620https://www.ebi.ac.uk/biostudies/studies/S-EPMC10698731biostudies-literatureA domino reaction for the synthesis of pyrrolo[2,1-<i>a</i>]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions.PMC10698731Yang ZLuo ZWang CHu HWang YfalseA domino reaction for the synthesis of pyrrolo[2,1-<i>a</i>]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions.Pyrrolo[2,1-<i>a</i>]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes <i>via</i> an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process. This reaction was promoted by a four-component catalytic system which included [RuCl₂(<i>p</i>-cymene)]₂, CuCl, copper acetate monohydrate and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) under aerobic conditions.2023-01-01T00:00:00Z2023 Nov2025-04-05T10:49:36.504Z2025-04-05T10:49:36.504ZS-EPMC106987313807797210.1039/d3ra07653a