biostudies-literatureKaps LElse Kröner Research College9930902https://www.ebi.ac.uk/biostudies/studies/S-EPMC10700970biostudies-literatureUnknown2023<h4>Background</h4>Systemic inflammation with elevated inflammatory cytokines is a hallmark in patients with cirrhosis and the main driver of decompensation. There is insufficient data on whether inflammatory cytokine levels differ between hepatic and jugular veins, which may have implications for further immunological studies.<h4>Methods</h4>Blood from the hepatic and jugular veins of 40 patients with cirrhosis was collected during hepatic venous pressure gradient (HVPG) measurements. Serum levels of 13 inflammatory cytokines (IL-1<i>β</i>, Int-<i>α</i>2, Int-<i>γ</i>, TNF-<i>α</i>, MCP-1, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, and IL-33) were quantified by cytometric bead array.<h4>Results</h4>Cytokine levels of IFN-<i>α</i>2, IFN-<i>γ</i>, TNF-<i>α</i>, IL-6, IL-8, IL-10, ILMediators of inflammationComparison of Inflammatory Cytokine Levels in Hepatic and Jugular Veins of Patients with Cirrhosis.PMC107009702018_Kolleg.05Grabbe SGairing SJGehring SWorns MAKaps LSchattenberg JMLabenz CMedina-Montano CBros MSchleicher EMGalle PRNagel MfalseComparison of Inflammatory Cytokine Levels in Hepatic and Jugular Veins of Patients with Cirrhosis.<h4>Background</h4>Systemic inflammation with elevated inflammatory cytokines is a hallmark in patients with cirrhosis and the main driver of decompensation. There is insufficient data on whether inflammatory cytokine levels differ between hepatic and jugular veins, which may have implications for further immunological studies.<h4>Methods</h4>Blood from the hepatic and jugular veins of 40 patients with cirrhosis was collected during hepatic venous pressure gradient (HVPG) measurements. Serum levels of 13 inflammatory cytokines (IL-1<i>β</i>, Int-<i>α</i>2, Int-<i>γ</i>, TNF-<i>α</i>, MCP-1, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, and IL-33) were quantified by cytometric bead array.<h4>Results</h4>Cytokine levels of IFN-<i>α</i>2, IFN-<i>γ</i>, TNF-<i>α</i>, IL-6, IL-8, IL-10, IL2023-01-01T00:00:00Z20232026-06-03T08:03:13.588Z2025-04-04T03:29:46.472ZS-EPMC107009703807722810.1155/2023/9930902