{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Frezal L"],"funding":["Agence Nationale de la Recherche","College of Natural Resources and Sciences, Humboldt State University","Fondation pour la Recherche Médicale","NIH HHS"],"pagination":["e58116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10702804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(12)"],"pubmed_abstract":["The animal germline lineage needs to be maintained along generations. However, some Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to sterility after several generations at 25°C. Using a genome-wide association approach, we detect a significant peak on chromosome III around 5 Mb, confirmed by introgressions. Thus, a seemingly deleterious genotype is maintained at intermediate frequency in the species. Environmental rescue is a likely explanation, and indeed associated bacteria and microsporidia suppress the phenotype of wild isolates as well as mutants in small RNA inheritance (nrde-2) and histone modifications (set-2). Escherichia coli strains of the K-12 lineage suppress the phenotype compared to B strains. By shifting a wild strain from E. coli K-12 to"],"journal":["EMBO reports"],"pubmed_title":["Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans."],"pmcid":["PMC10702804"],"funding_grant_id":["FDT202106013206","ARF202209015859","ANR‐14‐CE10‐0003","P40 OD010440","ANR‐19‐CE12‐0025"],"pubmed_authors":["Zhang G","Richaud A","Noble L","Saglio M","Felix MA","Frezal L"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans.","description":"The animal germline lineage needs to be maintained along generations. However, some Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to sterility after several generations at 25°C. Using a genome-wide association approach, we detect a significant peak on chromosome III around 5 Mb, confirmed by introgressions. Thus, a seemingly deleterious genotype is maintained at intermediate frequency in the species. Environmental rescue is a likely explanation, and indeed associated bacteria and microsporidia suppress the phenotype of wild isolates as well as mutants in small RNA inheritance (nrde-2) and histone modifications (set-2). Escherichia coli strains of the K-12 lineage suppress the phenotype compared to B strains. By shifting a wild strain from E. coli K-12 to","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-06-03T00:21:10.385Z","creation":"2025-04-04T23:31:10.842Z"},"accession":"S-EPMC10702804","cross_references":{"pubmed":["37983674"],"doi":["10.15252/embr.202358116"]}}