{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Wang H"],"funding":["NCI NIH HHS","NIH HHS"],"pubmed_abstract":["The \"Mlx\" and \"Myc\" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that body-wide <i>Mlx</i> inactivation, like that of <i>Myc,</i> accelerates numerous aging-related phenotypes pertaining to body habitus and metabolism. The deregulation of numerous aging-related Myc target gene sets is also accelerated. Among other functions, these gene sets often regulate ribosomal and mitochondrial structure and function, genomic stability and aging. Whereas \"<i>Myc</i>KO\" mice have an extended lifespan because of a lower cancer incidence, \"<i>Mlx</i>KO\" mice have normal lifespans and a somewhat higher cancer incidence. Li"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.11.26.568749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10705233"],"repository":["biostudies-literature"],"pubmed_title":["The Myc-Like Mlx Network Impacts Aging and Metabolism."],"pmcid":["PMC10705233"],"funding_grant_id":["R01 CA174713","S10 OD028483"],"pubmed_authors":["Stevens T","Land CV","Roberts A","Lu J","Muzumdar R","Vockley J","Wang H","Prochownik EV","Gong Z"],"additional_accession":[]},"is_claimable":false,"name":"The Myc-Like Mlx Network Impacts Aging and Metabolism.","description":"The \"Mlx\" and \"Myc\" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that body-wide <i>Mlx</i> inactivation, like that of <i>Myc,</i> accelerates numerous aging-related phenotypes pertaining to body habitus and metabolism. The deregulation of numerous aging-related Myc target gene sets is also accelerated. Among other functions, these gene sets often regulate ribosomal and mitochondrial structure and function, genomic stability and aging. Whereas \"<i>Myc</i>KO\" mice have an extended lifespan because of a lower cancer incidence, \"<i>Mlx</i>KO\" mice have normal lifespans and a somewhat higher cancer incidence. Li","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-12T03:11:57.657Z","creation":"2025-04-05T11:15:04.415Z"},"accession":"S-EPMC10705233","cross_references":{"pubmed":["38076995"],"doi":["10.1101/2023.11.26.568749"]}}