biostudies-literatureUnknownWang HNCI NIH HHSNIH HHSThe "Mlx" and "Myc" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that body-wide <i>Mlx</i> inactivation, like that of <i>Myc,</i> accelerates numerous aging-related phenotypes pertaining to body habitus and metabolism. The deregulation of numerous aging-related Myc target gene sets is also accelerated. Among other functions, these gene sets often regulate ribosomal and mitochondrial structure and function, genomic stability and aging. Whereas "<i>Myc</i>KO" mice have an extended lifespan because of a lower cancer incidence, "<i>Mlx</i>KO" mice have normal lifespans and a somewhat higher cancer incidence. LibioRxiv : the preprint server for biology2023.11.26.568749https://www.ebi.ac.uk/biostudies/studies/S-EPMC10705233biostudies-literatureThe Myc-Like Mlx Network Impacts Aging and Metabolism.PMC10705233R01 CA174713S10 OD028483Stevens TLand CVRoberts ALu JMuzumdar RVockley JWang HProchownik EVGong ZfalseThe Myc-Like Mlx Network Impacts Aging and Metabolism.The "Mlx" and "Myc" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that body-wide <i>Mlx</i> inactivation, like that of <i>Myc,</i> accelerates numerous aging-related phenotypes pertaining to body habitus and metabolism. The deregulation of numerous aging-related Myc target gene sets is also accelerated. Among other functions, these gene sets often regulate ribosomal and mitochondrial structure and function, genomic stability and aging. Whereas "<i>Myc</i>KO" mice have an extended lifespan because of a lower cancer incidence, "<i>Mlx</i>KO" mice have normal lifespans and a somewhat higher cancer incidence. Li2023-01-01T00:00:00Z2023 Nov2026-06-12T03:11:57.657Z2025-04-05T11:15:04.415ZS-EPMC107052333807699510.1101/2023.11.26.568749