{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang Y"],"funding":["NIH HHS"],"pagination":["5552"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10705754"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(23)"],"pubmed_abstract":["Epithelial cell adhesion molecule (EpCAM) is a tumor-associated antigen that is frequently overexpressed in various carcinomas. We have developed chimeric antigen receptor (CAR) T cells specifically targeting EpCAM for the treatment of gastric cancer. This study sought to unravel the precise mechanisms by which tumors evade immune surveillance and develop resistance to CAR T cell therapy. Through a combination of whole-body CAR T cell imaging and single-cell multiomic analyses, we uncovered intricate interactions between tumors and tumor-infiltrating lymphocytes (TILs). In a gastric cancer model, tumor-infiltrating CD8 T cells exhibited both cytotoxic and exhausted phenotypes, while CD4 T cells were mainly regulatory T cells. A T cell receptor (TCR) clonal analysis provided evidence of CAR"],"journal":["Cancers"],"pubmed_title":["Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance."],"pmcid":["PMC10705754"],"funding_grant_id":["R01-CA217059","R01-CA254035"],"pubmed_authors":["Jin MM","Yang Y","Louie R","Puc J","Alcaina Y","Vedvyas Y","Luciani F","Min IM","Britz M"],"additional_accession":[]},"is_claimable":false,"name":"Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance.","description":"Epithelial cell adhesion molecule (EpCAM) is a tumor-associated antigen that is frequently overexpressed in various carcinomas. We have developed chimeric antigen receptor (CAR) T cells specifically targeting EpCAM for the treatment of gastric cancer. This study sought to unravel the precise mechanisms by which tumors evade immune surveillance and develop resistance to CAR T cell therapy. Through a combination of whole-body CAR T cell imaging and single-cell multiomic analyses, we uncovered intricate interactions between tumors and tumor-infiltrating lymphocytes (TILs). In a gastric cancer model, tumor-infiltrating CD8 T cells exhibited both cytotoxic and exhausted phenotypes, while CD4 T cells were mainly regulatory T cells. A T cell receptor (TCR) clonal analysis provided evidence of CAR","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-25T21:17:52.341Z","creation":"2025-04-06T08:40:59.187Z"},"accession":"S-EPMC10705754","cross_references":{"pubmed":["38067255"],"doi":["10.3390/cancers15235552"]}}