{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mougin C"],"funding":["Agence Nationale de la Recherche","National Agency of Research (ANR France)"],"pagination":["4199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10706458"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(23)"],"pubmed_abstract":["Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term memory and long-term memory and anxiety-like behavior and improves the stress response in aged mice. The aim of this study was to determine the effects of a fish hydrolysate enriched with EPA/DHA or not on the cognitive ability and social interaction during aging and the biological mechanisms involved. We showed for the first time that a fish hydrolysate enriched with EPA/DHA or not improved memory performance and preference for social novelty that were diminished by aging. These changes were associated with the modulation of the gut microbiota, normalizat"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging."],"pmcid":["PMC10706458"],"funding_grant_id":["ANR 21-PRRD-0058-01","21-PRRD-0058-01"],"pubmed_authors":["Joffre C","Pallet V","Leyrolle Q","Bouvret E","Laye S","Mougin C","Lucas C","Chataigner M","Dinel AL"],"additional_accession":[]},"is_claimable":false,"name":"Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging.","description":"Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term memory and long-term memory and anxiety-like behavior and improves the stress response in aged mice. The aim of this study was to determine the effects of a fish hydrolysate enriched with EPA/DHA or not on the cognitive ability and social interaction during aging and the biological mechanisms involved. We showed for the first time that a fish hydrolysate enriched with EPA/DHA or not improved memory performance and preference for social novelty that were diminished by aging. These changes were associated with the modulation of the gut microbiota, normalizat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-05-30T03:10:32.65Z","creation":"2025-04-05T12:40:05.481Z"},"accession":"S-EPMC10706458","cross_references":{"pubmed":["38231613"],"doi":["10.3390/foods12234199"]}}