biostudies-literatureMougin CAgence Nationale de la RechercheNational Agency of Research (ANR France)4199https://www.ebi.ac.uk/biostudies/studies/S-EPMC10706458biostudies-literatureUnknown12(23)Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term memory and long-term memory and anxiety-like behavior and improves the stress response in aged mice. The aim of this study was to determine the effects of a fish hydrolysate enriched with EPA/DHA or not on the cognitive ability and social interaction during aging and the biological mechanisms involved. We showed for the first time that a fish hydrolysate enriched with EPA/DHA or not improved memory performance and preference for social novelty that were diminished by aging. These changes were associated with the modulation of the gut microbiota, normalizatFoods (Basel, Switzerland)Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging.PMC10706458ANR 21-PRRD-0058-0121-PRRD-0058-01Joffre CPallet VLeyrolle QBouvret ELaye SMougin CLucas CChataigner MDinel ALfalseDietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging.Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term memory and long-term memory and anxiety-like behavior and improves the stress response in aged mice. The aim of this study was to determine the effects of a fish hydrolysate enriched with EPA/DHA or not on the cognitive ability and social interaction during aging and the biological mechanisms involved. We showed for the first time that a fish hydrolysate enriched with EPA/DHA or not improved memory performance and preference for social novelty that were diminished by aging. These changes were associated with the modulation of the gut microbiota, normalizat2023-01-01T00:00:00Z2023 Nov2026-05-30T03:10:32.65Z2025-04-05T12:40:05.481ZS-EPMC107064583823161310.3390/foods12234199