{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Babu N"],"funding":["Centers for Disease Control and Prevention","Biotechnology Industry Research Assistance Council"],"pagination":["100269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10709682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19"],"pubmed_abstract":["<h4>Background</h4>Chikungunya disease (CHIKD) is a threat to global health, as it impairs the quality of life of an infected individual ranging from months to years. A systematic evaluation of the serological, virological, and immunological aspects of the circulating viruses and their impact on the host response is imperative for better understanding of the evolving disease dynamics.<h4>Methods</h4>Serum samples were collected from 196 acute CHIKD patients from ten tertiary care hospitals across India during 2016-2021. Out of 196 patients, paired convalescent samples were collected from 51 patients (one-month post-onset of symptoms). The serum samples were profiled for cytokines and neutralisation capacity. Further, chikungunya virus (CHIKV) was isolated from the acute sera and the replic"],"journal":["The Lancet regional health. Southeast Asia"],"pubmed_title":["Cytokine profile, neutralisation potential and viral replication dynamics in sera of chikungunya patients in India: a cross-sectional study."],"pmcid":["PMC10709682"],"funding_grant_id":["BT/NBM0101/02/18"],"pubmed_authors":["Shastri JS","Shetty U","Pani SS","Babu N","Jayaram A","Agarwal S","Ibemgbo SA","Sunil S","Jagadesh A","Mahilkar S","Sudandiradas R","Kumar PS","Mudgal PP","Ratho PK","Mathur G","Mishra B","Chattopadhyay S","Singh S"],"additional_accession":[]},"is_claimable":false,"name":"Cytokine profile, neutralisation potential and viral replication dynamics in sera of chikungunya patients in India: a cross-sectional study.","description":"<h4>Background</h4>Chikungunya disease (CHIKD) is a threat to global health, as it impairs the quality of life of an infected individual ranging from months to years. A systematic evaluation of the serological, virological, and immunological aspects of the circulating viruses and their impact on the host response is imperative for better understanding of the evolving disease dynamics.<h4>Methods</h4>Serum samples were collected from 196 acute CHIKD patients from ten tertiary care hospitals across India during 2016-2021. Out of 196 patients, paired convalescent samples were collected from 51 patients (one-month post-onset of symptoms). The serum samples were profiled for cytokines and neutralisation capacity. Further, chikungunya virus (CHIKV) was isolated from the acute sera and the replic","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-29T02:01:21.909Z","creation":"2025-05-29T20:43:59.634Z"},"accession":"S-EPMC10709682","cross_references":{"pubmed":["38076718"],"doi":["10.1016/j.lansea.2023.100269"]}}