biostudies-literatureBabu NCenters for Disease Control and PreventionBiotechnology Industry Research Assistance Council100269https://www.ebi.ac.uk/biostudies/studies/S-EPMC10709682biostudies-literatureUnknown19<h4>Background</h4>Chikungunya disease (CHIKD) is a threat to global health, as it impairs the quality of life of an infected individual ranging from months to years. A systematic evaluation of the serological, virological, and immunological aspects of the circulating viruses and their impact on the host response is imperative for better understanding of the evolving disease dynamics.<h4>Methods</h4>Serum samples were collected from 196 acute CHIKD patients from ten tertiary care hospitals across India during 2016-2021. Out of 196 patients, paired convalescent samples were collected from 51 patients (one-month post-onset of symptoms). The serum samples were profiled for cytokines and neutralisation capacity. Further, chikungunya virus (CHIKV) was isolated from the acute sera and the replicThe Lancet regional health. Southeast AsiaCytokine profile, neutralisation potential and viral replication dynamics in sera of chikungunya patients in India: a cross-sectional study.PMC10709682BT/NBM0101/02/18Shastri JSShetty UPani SSBabu NJayaram AAgarwal SIbemgbo SASunil SJagadesh AMahilkar SSudandiradas RKumar PSMudgal PPRatho PKMathur GMishra BChattopadhyay SSingh SfalseCytokine profile, neutralisation potential and viral replication dynamics in sera of chikungunya patients in India: a cross-sectional study.<h4>Background</h4>Chikungunya disease (CHIKD) is a threat to global health, as it impairs the quality of life of an infected individual ranging from months to years. A systematic evaluation of the serological, virological, and immunological aspects of the circulating viruses and their impact on the host response is imperative for better understanding of the evolving disease dynamics.<h4>Methods</h4>Serum samples were collected from 196 acute CHIKD patients from ten tertiary care hospitals across India during 2016-2021. Out of 196 patients, paired convalescent samples were collected from 51 patients (one-month post-onset of symptoms). The serum samples were profiled for cytokines and neutralisation capacity. Further, chikungunya virus (CHIKV) was isolated from the acute sera and the replic2023-01-01T00:00:00Z2023 Dec2026-05-29T02:01:21.909Z2025-05-29T20:43:59.634ZS-EPMC107096823807671810.1016/j.lansea.2023.100269