{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bugnon Q"],"funding":["Swiss National Science Foundation"],"pubmed_abstract":["The antibacterial activity of 22 thiolato-bridged dinuclear ruthenium(II)-arene compounds was assessed <i>in vitro</i> against <i>Escherichia coli</i>, <i>Streptococcus pneumoniae</i>, and <i>Staphylococcus aureus</i>. None of the compounds efficiently inhibited the growth of the three <i>E. coli</i> strains tested, and only compound <b>5</b> exhibited a medium activity against this bacterium [MIC (minimum inhibitory concentration) of 25 µM]. However, a significant antibacterial activity was observed against <i>S. pneumoniae</i>, with MIC values ranging from 1.3 to 2.6 µM for compounds <b>1-3</b>, <b>5,</b> and <b>6</b>. Similarly, compounds <b>2</b>, <b>5-7,</b> and <b>20-22</b> had MIC values ranging from 2.5 to 5 µM against <i>S. aureus</i>. The tested diruthenium compounds have a bacte"],"journal":["Microbiology spectrum"],"pagination":["e0095423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10714934"],"repository":["biostudies-literature"],"pubmed_title":["<i>In vitro</i> antibacterial activity of dinuclear thiolato-bridged ruthenium(II)-arene compounds."],"pmcid":["PMC10714934"],"funding_grant_id":["CRSII5-173718"],"pubmed_authors":["Bugnon Q","Holzer I","Hilty M","Desiatkina O","Paunescu E","Melendez C","Fayolles de Chaptes L","Furrer J"],"additional_accession":[]},"is_claimable":false,"name":"<i>In vitro</i> antibacterial activity of dinuclear thiolato-bridged ruthenium(II)-arene compounds.","description":"The antibacterial activity of 22 thiolato-bridged dinuclear ruthenium(II)-arene compounds was assessed <i>in vitro</i> against <i>Escherichia coli</i>, <i>Streptococcus pneumoniae</i>, and <i>Staphylococcus aureus</i>. None of the compounds efficiently inhibited the growth of the three <i>E. coli</i> strains tested, and only compound <b>5</b> exhibited a medium activity against this bacterium [MIC (minimum inhibitory concentration) of 25 µM]. However, a significant antibacterial activity was observed against <i>S. pneumoniae</i>, with MIC values ranging from 1.3 to 2.6 µM for compounds <b>1-3</b>, <b>5,</b> and <b>6</b>. Similarly, compounds <b>2</b>, <b>5-7,</b> and <b>20-22</b> had MIC values ranging from 2.5 to 5 µM against <i>S. aureus</i>. The tested diruthenium compounds have a bacte","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-04T14:32:09.421Z","creation":"2025-04-04T14:32:09.421Z"},"accession":"S-EPMC10714934","cross_references":{"pubmed":["37815336"],"doi":["10.1128/spectrum.00954-23"]}}