biostudies-literatureLaCroix ISNHLBI NIH HHSNIGMS NIH HHSe1299-e1312https://www.ebi.ac.uk/biostudies/studies/S-EPMC10728352biostudies-literatureUnknown278(6)<h4>Objective</h4>Advanced mass spectrometry methods were leveraged to analyze both proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and hemorrhagic shock (HS)-isolated or combined-in a swine model, followed by correlation to viscoelastic measurements of coagulopathy via thrombelastography.<h4>Background</h4>TI and HS cause distinct molecular changes in plasma in both animal models and trauma patients. However, the contribution to coagulopathy of trauma, the leading cause of preventable mortality in this patient population remains unclear. The recent development of a swine model for isolated or combined TI+HS facilitated the current study.<h4>Methods</h4>Male swine (n=17) were randomized to either isolated or combined TI and HS. Coagulation status was anaAnnals of surgeryOmics Signatures of Tissue Injury and Hemorrhagic Shock in Swine.PMC10728352R01 HL146442T32 GM008315R01 HL161004R01 HL149714R01 HL148151RM1 GM131968Silliman CD'Alessandro ADzieciatkowska MCohen MLaCroix ISMoore EECendali FIHom PHansen KCMitra SSauaia ACralley AfalseOmics Signatures of Tissue Injury and Hemorrhagic Shock in Swine.<h4>Objective</h4>Advanced mass spectrometry methods were leveraged to analyze both proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and hemorrhagic shock (HS)-isolated or combined-in a swine model, followed by correlation to viscoelastic measurements of coagulopathy via thrombelastography.<h4>Background</h4>TI and HS cause distinct molecular changes in plasma in both animal models and trauma patients. However, the contribution to coagulopathy of trauma, the leading cause of preventable mortality in this patient population remains unclear. The recent development of a swine model for isolated or combined TI+HS facilitated the current study.<h4>Methods</h4>Male swine (n=17) were randomized to either isolated or combined TI and HS. Coagulation status was ana2023-01-01T00:00:00Z2023 Dec2025-04-18T16:51:59.825Z2025-04-07T04:19:25.228ZS-EPMC107283523733468010.1097/SLA.000000000000594410.1097/sla.0000000000005944