{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Canonico F"],"funding":["British Heart Foundation","European Research Council"],"pagination":["2653-2662"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10730239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(16)"],"pubmed_abstract":["Aims
The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter 1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI).Methods and results
We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HSs). NSTEMI patients showed higher expression of GLUT-1 and an enhanced glucose uptake in T cells when compared with CCS patients (P < 0.0001; P = 0.0101, "],"journal":["Cardiovascular research"],"pubmed_title":["GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation."],"pmcid":["PMC10730239"],"funding_grant_id":["PG/19/84/34771","FS/4yPhD/F/20/34127A, PG/19/84/34771, FS/19/56/34893A, PG/21/10541, PG/21/10634","726318","ERC-CoG-726318"],"pubmed_authors":["Di Sario M","Liuzzo G","d'Aiello A","Pedicino D","Angelini G","Severino A","Wierzbicki K","D'Amario D","Canonico F","Ciampi P","Montone RA","Massetti M","Russo S","De Ciutiis A","Baldi A","Vinci R","Ponzo M","Szczepaniak P","Flego D","Bonanni A","Pisano E","Crea F","Kapelak B","Guzik TJ"],"additional_accession":[]},"is_claimable":false,"name":"GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation.","description":"Aims
The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter 1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI).Methods and results
We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HSs). NSTEMI patients showed higher expression of GLUT-1 and an enhanced glucose uptake in T cells when compared with CCS patients (P < 0.0001; P = 0.0101, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-22T08:20:29.27Z","creation":"2024-11-21T06:44:03.971Z"},"accession":"S-EPMC10730239","cross_references":{"pubmed":["36508576"],"doi":["10.1093/cvr/cvac184"]}}