biostudies-literatureCanonico FBritish Heart FoundationEuropean Research Council2653-2662https://www.ebi.ac.uk/biostudies/studies/S-EPMC10730239biostudies-literatureUnknown119(16)<h4>Aims</h4>The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter 1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI).<h4>Methods and results</h4>We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HSs). NSTEMI patients showed higher expression of GLUT-1 and an enhanced glucose uptake in T cells when compared with CCS patients (P < 0.0001; P = 0.0101, Cardiovascular researchGLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation.PMC10730239PG/19/84/34771FS/4yPhD/F/20/34127A, PG/19/84/34771, FS/19/56/34893A, PG/21/10541, PG/21/10634726318ERC-CoG-726318Di Sario MLiuzzo Gd'Aiello APedicino DAngelini GSeverino AWierzbicki KD'Amario DCanonico FCiampi PMontone RAMassetti MRusso SDe Ciutiis ABaldi AVinci RPonzo MSzczepaniak PFlego DBonanni APisano ECrea FKapelak BGuzik TJfalseGLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation.<h4>Aims</h4>The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter 1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI).<h4>Methods and results</h4>We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HSs). NSTEMI patients showed higher expression of GLUT-1 and an enhanced glucose uptake in T cells when compared with CCS patients (P < 0.0001; P = 0.0101, 2023-01-01T00:00:00Z2023 Dec2025-04-22T08:20:29.27Z2024-11-21T06:44:03.971ZS-EPMC107302393650857610.1093/cvr/cvac184