{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee YC"],"funding":["Ministry of Science and Technology, Taiwan","Chang Gung Memorial Hospital, Linkou"],"pagination":["1547-1556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10731513"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(6)"],"pubmed_abstract":["<h4>Objectives</h4>This study aimed to investigate the association between salivary matrix metalloproteinase-1 (MMP-1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP-1 and other established circulating markers for OSCC.<h4>Methods</h4>Saliva specimens from 479 OSCC subjects were examined using an enzyme-linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP-1 and other markers were calculated, and survival analyses were conducted using Kaplan-Meier and multivariate regression methods.<h4>Results</h4>Salivary MMP-1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, <i>p</i> = .021) and Charl"],"journal":["Laryngoscope investigative otolaryngology"],"pubmed_title":["Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer."],"pmcid":["PMC10731513"],"funding_grant_id":["CMRPG3J1253","CMRPG3M0101","MOST 111‐2314‐B‐182A‐078‐MY3"],"pubmed_authors":["Lee YC","Huang Y","Hung SY","Yu JS","Lu CY","Chang KP","Chang YT","Lee LY","Kao HK","Chang YS"],"additional_accession":[]},"is_claimable":false,"name":"Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer.","description":"<h4>Objectives</h4>This study aimed to investigate the association between salivary matrix metalloproteinase-1 (MMP-1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP-1 and other established circulating markers for OSCC.<h4>Methods</h4>Saliva specimens from 479 OSCC subjects were examined using an enzyme-linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP-1 and other markers were calculated, and survival analyses were conducted using Kaplan-Meier and multivariate regression methods.<h4>Results</h4>Salivary MMP-1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, <i>p</i> = .021) and Charl","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-07-14T15:36:29.029Z","creation":"2025-04-04T14:12:58.655Z"},"accession":"S-EPMC10731513","cross_references":{"pubmed":["38130271"],"doi":["10.1002/lio2.1166"]}}