biostudies-literatureLee YCMinistry of Science and Technology, TaiwanChang Gung Memorial Hospital, Linkou1547-1556https://www.ebi.ac.uk/biostudies/studies/S-EPMC10731513biostudies-literatureUnknown8(6)<h4>Objectives</h4>This study aimed to investigate the association between salivary matrix metalloproteinase-1 (MMP-1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP-1 and other established circulating markers for OSCC.<h4>Methods</h4>Saliva specimens from 479 OSCC subjects were examined using an enzyme-linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP-1 and other markers were calculated, and survival analyses were conducted using Kaplan-Meier and multivariate regression methods.<h4>Results</h4>Salivary MMP-1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, <i>p</i> = .021) and CharlLaryngoscope investigative otolaryngologyComparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer.PMC10731513CMRPG3J1253CMRPG3M0101MOST 111‐2314‐B‐182A‐078‐MY3Lee YCHuang YHung SYYu JSLu CYChang KPChang YTLee LYKao HKChang YSfalseComparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer.<h4>Objectives</h4>This study aimed to investigate the association between salivary matrix metalloproteinase-1 (MMP-1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP-1 and other established circulating markers for OSCC.<h4>Methods</h4>Saliva specimens from 479 OSCC subjects were examined using an enzyme-linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP-1 and other markers were calculated, and survival analyses were conducted using Kaplan-Meier and multivariate regression methods.<h4>Results</h4>Salivary MMP-1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, <i>p</i> = .021) and Charl2023-01-01T00:00:00Z2023 Dec2026-07-14T15:36:29.029Z2025-04-04T14:12:58.655ZS-EPMC107315133813027110.1002/lio2.1166