{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoerres R"],"funding":["U.S. Nuclear Regulatory Commission"],"pagination":["20688-20698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10732151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(50)"],"pubmed_abstract":["Metal complexes with the general formula [M<sup>I</sup>(CO)<sub>3</sub>(k<sup>3</sup>-L)]<sup>+</sup>, where M = Re, <sup>186</sup>Re, or <sup>99m</sup>Tc and L = 1,4,7-triazacyclononane (TACN), NOTA, or NODAGA chelators, have previously been conjugated to peptide-based biological targeting vectors and investigated as potential theranostic radiopharmaceuticals. The promising results demonstrated by these bioconjugate complexes prompted our exploration of other TACN-based chelators for suitability for (radio)labeling with the [M(CO)<sub>3</sub>]<sup>+</sup> core. In this work, we investigated the role of the TACN pendant arms in complexation of the [M(CO)<sub>3</sub>]<sup>+</sup> core through (radio)labeling of TACN chelators bearing acid, ester, mixed acid-ester, or no pendant functional g"],"journal":["Inorganic chemistry"],"pubmed_title":["1,4,7-Triazacyclononane-Based Chelators for the Complexation of [<sup>186</sup>Re]Re- and [<sup>99m</sup>Tc]Tc-Tricarbonyl Cores."],"pmcid":["PMC10732151"],"funding_grant_id":["31310021M0040"],"pubmed_authors":["Hennkens HM","Hoerres R"],"additional_accession":[]},"is_claimable":false,"name":"1,4,7-Triazacyclononane-Based Chelators for the Complexation of [<sup>186</sup>Re]Re- and [<sup>99m</sup>Tc]Tc-Tricarbonyl Cores.","description":"Metal complexes with the general formula [M<sup>I</sup>(CO)<sub>3</sub>(k<sup>3</sup>-L)]<sup>+</sup>, where M = Re, <sup>186</sup>Re, or <sup>99m</sup>Tc and L = 1,4,7-triazacyclononane (TACN), NOTA, or NODAGA chelators, have previously been conjugated to peptide-based biological targeting vectors and investigated as potential theranostic radiopharmaceuticals. The promising results demonstrated by these bioconjugate complexes prompted our exploration of other TACN-based chelators for suitability for (radio)labeling with the [M(CO)<sub>3</sub>]<sup>+</sup> core. In this work, we investigated the role of the TACN pendant arms in complexation of the [M(CO)<sub>3</sub>]<sup>+</sup> core through (radio)labeling of TACN chelators bearing acid, ester, mixed acid-ester, or no pendant functional g","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-18T21:41:58.397Z","creation":"2025-02-19T02:33:51.172Z"},"accession":"S-EPMC10732151","cross_references":{"pubmed":["37683190"],"doi":["10.1021/acs.inorgchem.3c01934"]}}