{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alexandrou E"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["55-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10732280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["GC-rich sequences can fold into G-quadruplexes and i-motifs and are known to control gene expression in many organisms. The potent G-quadruplex experimental anticancer drug QN-302 down-regulates a number of cancer-related genes, in particular <i>S100P</i>. Here we show this ligand has strong opposing effects with i-motif DNA structures and is one of the most potent i-motif destabilising agents reported to date. QN-302 down-regulates the expression of numerous cancer-related genes by pan-quadruplex targeting. QN-302 exhibits exceptional combined synergistic effects compared to many other G-quadruplex and i-motif interacting compounds. This work further emphasises the importance of considering G-quadruplex and i-motif DNA structures as one dynamic system."],"journal":["Organic & biomolecular chemistry"],"pubmed_title":["QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene."],"pmcid":["PMC10732280"],"funding_grant_id":["BB/W001616/1"],"pubmed_authors":["Alexandrou E","Guneri D","Waller ZAE","Neidle S"],"additional_accession":[]},"is_claimable":false,"name":"QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene.","description":"GC-rich sequences can fold into G-quadruplexes and i-motifs and are known to control gene expression in many organisms. The potent G-quadruplex experimental anticancer drug QN-302 down-regulates a number of cancer-related genes, in particular <i>S100P</i>. Here we show this ligand has strong opposing effects with i-motif DNA structures and is one of the most potent i-motif destabilising agents reported to date. QN-302 down-regulates the expression of numerous cancer-related genes by pan-quadruplex targeting. QN-302 exhibits exceptional combined synergistic effects compared to many other G-quadruplex and i-motif interacting compounds. This work further emphasises the importance of considering G-quadruplex and i-motif DNA structures as one dynamic system.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-29T09:56:01.862Z","creation":"2025-04-06T19:20:23.171Z"},"accession":"S-EPMC10732280","cross_references":{"pubmed":["37970888"],"doi":["10.1039/d3ob01464a"]}}