{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo Y"],"funding":["111 Project","National Natural Science Foundation of China","Major Project of Science and Technology Innovation 2030","Swedish Research Council"],"pagination":["msad273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10735294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(12)"],"pubmed_abstract":["Rumpless chickens exhibit an abnormality in their tail development. The genetics and biology of this trait has been studied for decades to illustrate a broad variation in both the types of inheritance and the severity in the developmental defects of the tail. In this study, we created a backcross pedigree by intercrossing Piao (rumpless) with Xianju (normal) to investigate the genetic mechanisms and molecular basis of the rumpless trait in Piao chicken. Through genome-wide association and linkage analyses, the candidate region was fine-mapped to 798.5 kb (chromosome 2: 86.9 to 87.7 Mb). Whole-genome sequencing analyses identified a single variant, a 4.2 kb deletion, which was completely associated with the rumpless phenotype. Explorations of the expression data identified a novel causative"],"journal":["Molecular biology and evolution"],"pubmed_title":["Mapping and Functional Dissection of the Rumpless Trait in Piao Chicken Identifies a Causal Loss of Function Mutation in the Novel Gene Rum."],"pmcid":["PMC10735294"],"funding_grant_id":["31961133003","B12008","2018-05991"],"pubmed_authors":["Tian J","Li H","Carlborg O","Chen K","Guo Y","Hu X","Han W","Song C","Zhang S","Zhu C","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Mapping and Functional Dissection of the Rumpless Trait in Piao Chicken Identifies a Causal Loss of Function Mutation in the Novel Gene Rum.","description":"Rumpless chickens exhibit an abnormality in their tail development. The genetics and biology of this trait has been studied for decades to illustrate a broad variation in both the types of inheritance and the severity in the developmental defects of the tail. In this study, we created a backcross pedigree by intercrossing Piao (rumpless) with Xianju (normal) to investigate the genetic mechanisms and molecular basis of the rumpless trait in Piao chicken. Through genome-wide association and linkage analyses, the candidate region was fine-mapped to 798.5 kb (chromosome 2: 86.9 to 87.7 Mb). Whole-genome sequencing analyses identified a single variant, a 4.2 kb deletion, which was completely associated with the rumpless phenotype. Explorations of the expression data identified a novel causative","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-07-09T11:44:28.906Z","creation":"2025-04-06T16:28:00.58Z"},"accession":"S-EPMC10735294","cross_references":{"pubmed":["38069902"],"doi":["10.1093/molbev/msad273"]}}