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This policy has shifted toward selective application after guideline revision in 2014.<h4>Objective</h4>To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level.<h4>Design, setting, and participants</h4>This multicenter, population-based, nationwide cross-sectional cohort study analyzed Dutch patients with rectal cancer who were treated in 2011 with a 4-year follow-up. A similar study was performed in 2021, analyzing all patients that were surgically treated in","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-18T14:40:41.168Z","creation":"2025-04-07T00:57:38.262Z"},"accession":"S-EPMC10739079","cross_references":{"pubmed":["38127337"],"doi":["10.1001/jamaoncol.2023.5444"]}}