biostudies-literatureUnknown10(2)Hazen SJA<h4>Importance</h4>Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in 2014.<h4>Objective</h4>To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level.<h4>Design, setting, and participants</h4>This multicenter, population-based, nationwide cross-sectional cohort study analyzed Dutch patients with rectal cancer who were treated in 2011 with a 4-year follow-up. A similar study was performed in 2021, analyzing all patients that were surgically treated inJAMA oncology202-211https://www.ebi.ac.uk/biostudies/studies/S-EPMC10739079biostudies-literatureAbandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes.PMC10739079van der Burg SWvan Breest Smallenburg VZandvoort HJAvan Grevenstein WMUCompaan CSchreuder AMDinaux AMNonner JMarsman MSSchouten Nde Korte FIVrijland WWJou-Valencia DMierlo DPoortman PSchreurs WHvan Erp ACvan Dop IMPolat FBurghgraef TAPereboom ITAvan der Hoeven EJRJBrinkman DJWybenga JMNieuwenhuis JFBuijsen JVerwoerd-van Schaik HBahadoer RRBakker ISDogan KSmits ABvan der Wielen NKoster IMVermaas Mvan Rooijen SJvan der Zee DZwieten Tvan der Meij Wvan der Sande MESmakman Nden Dulk MJanssen PBraat MNGJACurutchet SBorstlap WAAMuller Kvan der Hagen SJHoogendoorn SRenger RJKusters MIntven MPWScheurkogel MMBosmans JWKool MEde Jong CEJNordkamp SKrul EJTPironet Zvan Duijvendijk PBemelman WABlok Jde Bie SHvan der Wolk STielbeek JAWBurbach JPMVasbinder GBCBradshaw JScheer Mvan der Valk MJMvan der Wolf FSWvan Hoorn FCeha HMGoense LFrietman BRaber Mde Nes LCFMieog JSDCrolla RMPHPaulusma Ivan Westreenen HLLettinga TNoordman BJSimons PCGSmalbroek BPvan den Berg COppedijk VDavids PHPSpaansen Bvan Kessel CPultrum BBRozema THarst ETemmink SJongen ACToorenvliet BRSlob MJVles WJPlate JDJvan Landeghem AAGVanhooymissen IJSvan Duyn EBImani FDijkstra FRde Mik SMLHorsthuis KVoets SVerschuur AVDVersluis-Ossenwaarde Lvan Sprundel TLahuis DLamme BMarres CCEl-Massoudi YLeseman-Hoogenboom MMvan Rees JMSluijmer HCEde Mey DJLSwank HAvan der Wolde JBlok RDCoene PPLOKrielen PDarbyshire TDekker ENBurger JWAvan Eekelen CMeerdink MGovaert MJPMKuiper JTPeringa JMadsen EAvenarius HHazen SJAde Graaf EJRSchoonderwoerd LKrdzalic JSmeenk RMVogelaar FJvan de Ven AWHVerduin WMDerkx-Hendriksen MPoodt IGMAlgie GDvan Tets WFde Haas RJSietses CFurnee EJBvan Gangelt Kvan den Nieuwboer JBJPaul PMPWitjes ACvan Koeverden SHakkenbrak NAGMenon AGVelema LAKetel JMAKok SCorver MBartels SABisschops RHCClermonts SMarijnen CAMvan Egdom LSEAnkersmit MBruns ERJBleeker WBorstlap JLips DJTen Hoeve HGReiber BMMVogelij CLABoogerd LSFBouvy NDOostdijk Mvan Bockel LWKetelaers SHJvan Dieren SJonker FHVerheijen PMAcherman YIZvan Beek SCMelenhorst JSchaafsma BEden Boer FCBonjer HJStraatman JDutch Snapshot Research GroupSteur Cvan Bastelaar JVeltkamp Svan Essen JAvan Tilborg AAJMZheng KJDeijen CLvan Gils REijlers BTuynman JBFeitsma EAZamaray BKlaase JKloppenberg FWHTen Cate DWGHeeren JFKorving JCDaniels-Gooszen AWCoebergh van den Braak RRJDroogh-de Greve KETip-Pluijm BAalbers AGJvan den Broek WTFerenschild Fvan der Schelling GFeshtali SSKruyt PMBangert FBuskens CJvan Wely BJVerdaasdonk EGGBastiaansen AJNMGerven PHeikens JTBuffart TEKolderman SEMMasselink IRoskott-Ten Brinke EADuijsens HMHvan der Hul RLWiering BHoogland PRothbarth JWetzel MMartens MHHendriksen EMLange JFHeres Pvan der Sluis MAmelung FJGeijsen EDSlooter GDVerhoef CQaderi SMConsten ECJHeemskerk JWijma AGOlthof PBOosterling SJSchuivens PMEde Groot IYauw STKInberg BEijsbouts QEde Groof EJDerksen Tvan Geel AAukema TSAlting von Geusau EBPrette JFNeijenhuis PAvan Elderen Svan Rossem CCBoer AHVeeken CJZorgdrager MGielkens HFassaert TWevers Kvan den Bosch Ivan den Hoek SPosma LAEBoerma EGBeets-Tan RGHPeeters KCMJTen Berge HASnijders HSOotes DDemirkiran AGerhards MFHeesink Vvan der Spek ABeets GLvan Woerden VNielen MJonkers Jvan der Bilt JDWRutten HJTWouters MWJMde Vries MBoute MCStoker JHompes RSchasfoort RARutten HWesterduin Evan der Zaag ESHuijbers ABarendse RMvan Hulst RBrandt-Kerkhof ARutten ARoosen LKeizers BSimkens GAvan Aalten SMSpillenaar-Bilgen EJLutke Holzik MFvan Steensel LBruin SHeijnen BMorsink LBraak SJTanis PJStam TCHavenga KVos-Westerman HAde Wit BWKHogewoning Ade Lijster MSEngelbrecht MWesterterp MFabry HFJMeijnen PTer Riele WWSonneveld DJADekker JWTde Vos Tot Nederveen Cappel RJLEmmen AMLHBouwman JEKortekaas RTJMoelker-Galuzina JBelgers EHJden Hartogh MDvan Trier DMamound ABosker RJIvan de Velde CJHSpruit PHCnossen JSHaen RAntonisse IEVijfhuize SZeestraten ECBrandsma ATASteller EHogewoning CRCSluckin TCMaas MSchaapman RVoeten SRombouts AJMBasha SLeijtens JWAKroese LFVerrijssen AEThorensen IMVerhagen TWit Fvan de Weijer MAJBeekhuis HMDSteup WHHoff CWegdam JAVroemen JCHarlaar JJRouw DBMulder EJTalsma AKvan Geloven AAWBakers FCHStortelder EZeilstra AGooszen JAHTseng LLogeman Fvan Tilborg FSchouten van der Velden APVerhaak TKnops EDunker MSvan Vugt BSTHogendoorn WKeijzer AKarthaus EGVliegen RFADuyck JNederend JBerbee MZimmerman DDEvan Loon YTGovaert JAvan Rijswijk AFoppen JWMusters GDThe GYMOtt Pvan Westerveld PPDiederik ALWoensdregt KAshruf JFde Wilt JHWfalseAbandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes.<h4>Importance</h4>Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in 2014.<h4>Objective</h4>To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level.<h4>Design, setting, and participants</h4>This multicenter, population-based, nationwide cross-sectional cohort study analyzed Dutch patients with rectal cancer who were treated in 2011 with a 4-year follow-up. A similar study was performed in 2021, analyzing all patients that were surgically treated in2024-01-01T00:00:00Z2024 Feb2025-04-18T14:40:41.168Z2025-04-07T00:57:38.262ZS-EPMC107390793812733710.1001/jamaoncol.2023.5444