{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang G"],"funding":["the financial support from the National Natural Science Foundation of China","the Natural Science Foundation of Anhui Province","Natural Science Foundation of Anhui Province","National Natural Science Foundation of China","Key Scientific Research Project in Colleges and the Universities of Anhui Province","the Key Scientific Research Project in Colleges and the Universities of Anhui Province"],"pagination":["631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10745014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(12)"],"pubmed_abstract":["Six previously undescribed cytosporone derivatives (phomotones A-E (<b>1</b>-<b>5</b>) and phomotone F (<b>13</b>)), two new spiro-alkanol phombistenes A-B (<b>14</b>-<b>15</b>), and seven known analogs (<b>6</b>-<b>12</b>) were isolated from the mangrove endophytic fungus <i>Phomopsis</i> sp. QYM-13. The structures of these compounds were elucidated using spectroscopic data analysis, electronic circular dichroism (ECD), and <sup>13</sup>C NMR calculations. Compound <b>14</b> features an unprecedented 1,6-dioxaspiro[4.5]decane ring system. All isolates were evaluated for their inhibitory effect on nitric oxide (NO) in LPS-induced RAW264.7 cells. The results showed that compounds <b>1</b>, <b>6</b>, <b>8,</b> and <b>11</b> exhibited potent bioactivities by comparing with positive control. T"],"journal":["Marine drugs"],"pubmed_title":["Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus <i>Phomopsis</i> sp. QYM-13."],"pmcid":["PMC10745014"],"funding_grant_id":["U20A2001","42276114","2308085QH302","2022AH050706","U20A2001, 42276114"],"pubmed_authors":["Li Z","Zhu J","She Z","Wang G","Chen Y","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus <i>Phomopsis</i> sp. QYM-13.","description":"Six previously undescribed cytosporone derivatives (phomotones A-E (<b>1</b>-<b>5</b>) and phomotone F (<b>13</b>)), two new spiro-alkanol phombistenes A-B (<b>14</b>-<b>15</b>), and seven known analogs (<b>6</b>-<b>12</b>) were isolated from the mangrove endophytic fungus <i>Phomopsis</i> sp. QYM-13. The structures of these compounds were elucidated using spectroscopic data analysis, electronic circular dichroism (ECD), and <sup>13</sup>C NMR calculations. Compound <b>14</b> features an unprecedented 1,6-dioxaspiro[4.5]decane ring system. All isolates were evaluated for their inhibitory effect on nitric oxide (NO) in LPS-induced RAW264.7 cells. The results showed that compounds <b>1</b>, <b>6</b>, <b>8,</b> and <b>11</b> exhibited potent bioactivities by comparing with positive control. T","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-14T03:19:29.263Z","creation":"2025-04-06T16:28:05.496Z"},"accession":"S-EPMC10745014","cross_references":{"pubmed":["38132952"],"doi":["10.3390/md21120631"]}}