{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["810-825"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10746262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133(10)"],"pubmed_abstract":["<h4>Background</h4>Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to standard drug therapy. A genome-wide association study may agnostically identify biomarkers and provide novel insight into the biology of myocardial recovery in DCM.<h4>Methods</h4>A genome-wide association study for change in left ventricular ejection fraction was performed in 686 White subjects with recent-onset DCM who received standard pharmacotherapy. Genome-wide association study signals were subsequently functionally validated and studied in relevant cellular models to understand molecular mechanisms that may have contributed to the change i"],"journal":["Circulation research"],"pubmed_title":["Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis."],"pmcid":["PMC10746262"],"funding_grant_id":["R01 HL075038","T32 GM008685","R01 HL116906","R01 HL069071","R01 HL164634"],"pubmed_authors":["McNamara DM","Jenkins GD","Skime MK","Barlera S","Starling RC","Sahni J","Gao H","Nguyen TTL","Cooper LT","Wang M","Mestroni L","Pinet F","de Groote P","Weinshilboum RM","Murthy V","Krejci J","Pereira NL","Tschumperlin DJ","Chaloupka A","Vyas H","Sinagra G","Philips TJ","Batzler A","Miller JD","Merlo M","Liu D","Pileggi S"],"additional_accession":[]},"is_claimable":false,"name":"Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis.","description":"<h4>Background</h4>Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to standard drug therapy. A genome-wide association study may agnostically identify biomarkers and provide novel insight into the biology of myocardial recovery in DCM.<h4>Methods</h4>A genome-wide association study for change in left ventricular ejection fraction was performed in 686 White subjects with recent-onset DCM who received standard pharmacotherapy. Genome-wide association study signals were subsequently functionally validated and studied in relevant cellular models to understand molecular mechanisms that may have contributed to the change i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-01T19:43:44.303Z","creation":"2025-04-19T17:28:00.795Z"},"accession":"S-EPMC10746262","cross_references":{"pubmed":["37800334"],"doi":["10.1161/CIRCRESAHA.123.323200","10.1161/circresaha.123.323200"]}}