biostudies-literatureLiu DNHLBI NIH HHSNIGMS NIH HHS810-825https://www.ebi.ac.uk/biostudies/studies/S-EPMC10746262biostudies-literatureUnknown133(10)<h4>Background</h4>Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to standard drug therapy. A genome-wide association study may agnostically identify biomarkers and provide novel insight into the biology of myocardial recovery in DCM.<h4>Methods</h4>A genome-wide association study for change in left ventricular ejection fraction was performed in 686 White subjects with recent-onset DCM who received standard pharmacotherapy. Genome-wide association study signals were subsequently functionally validated and studied in relevant cellular models to understand molecular mechanisms that may have contributed to the change iCirculation researchMyocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis.PMC10746262R01 HL075038T32 GM008685R01 HL116906R01 HL069071R01 HL164634McNamara DMJenkins GDSkime MKBarlera SStarling RCSahni JGao HNguyen TTLCooper LTWang MMestroni LPinet Fde Groote PWeinshilboum RMMurthy VKrejci JPereira NLTschumperlin DJChaloupka AVyas HSinagra GPhilips TJBatzler AMiller JDMerlo MLiu DPileggi SfalseMyocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis.<h4>Background</h4>Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to standard drug therapy. A genome-wide association study may agnostically identify biomarkers and provide novel insight into the biology of myocardial recovery in DCM.<h4>Methods</h4>A genome-wide association study for change in left ventricular ejection fraction was performed in 686 White subjects with recent-onset DCM who received standard pharmacotherapy. Genome-wide association study signals were subsequently functionally validated and studied in relevant cellular models to understand molecular mechanisms that may have contributed to the change i2023-01-01T00:00:00Z2023 Oct2026-06-01T19:43:44.303Z2025-04-19T17:28:00.795ZS-EPMC107462623780033410.1161/CIRCRESAHA.123.32320010.1161/circresaha.123.323200